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SMIM26 small integral membrane protein 26 [ Homo sapiens (human) ]

Gene ID: 388789, updated on 4-Jan-2025

Summary

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Official Symbol
SMIM26provided by HGNC
Official Full Name
small integral membrane protein 26provided by HGNC
Primary source
HGNC:HGNC:43430
See related
Ensembl:ENSG00000232388 AllianceGenome:HGNC:43430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINC00493
Summary
Enables protein kinase binding activity and transmembrane transporter binding activity. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in ovary (RPKM 42.1), adrenal (RPKM 38.6) and 25 other tissues See more
Orthologs
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Genomic context

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See SMIM26 in Genome Data Viewer
Location:
20p11.23
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (18567432..18569611)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (18618488..18620664)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18548076..18550255)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17591 Neighboring gene ribosomal protein S19 pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:18504796-18505995 Neighboring gene SEC23 homolog B, COPII coat complex component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17592 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:18547927-18548209 Neighboring gene uncharacterized LOC124904878 Neighboring gene Sharpr-MPRA regulatory region 13138 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:18568835-18569334 Neighboring gene RNA, 7SL, cytoplasmic 638, pseudogene Neighboring gene D-aminoacyl-tRNA deacylase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Investigation of LINC00493/SMIM26 Gene Suggests Its Dual Functioning at mRNA and Protein Level. Konina D, et al. Int J Mol Sci, 2021 Aug 6. PMID 34445188, Free PMC Article
  2. Identification and analysis of short open reading frames (sORFs) in the initially annotated noncoding RNA LINC00493 from human cells. Yeasmin F, et al. J Biochem, 2021 Apr 29. PMID 33386847
  3. LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma. Meng K, et al. EMBO Rep, 2023 Jun 5. PMID 37009826, Free PMC Article
  4. Co-expression Network Analysis of Human lncRNAs and Cancer Genes. Cogill SB, et al. Cancer Inform, 2014. PMID 25392693, Free PMC Article
  5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma.
    Title: LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma.
  2. Investigation of LINC00493/SMIM26 Gene Suggests Its Dual Functioning at mRNA and Protein Level.
    Title: Investigation of LINC00493/SMIM26 Gene Suggests Its Dual Functioning at mRNA and Protein Level.
  3. Identification and analysis of short open reading frames (sORFs) in the initially annotated noncoding RNA LINC00493 from human cells.
    Title: Identification and analysis of short open reading frames (sORFs) in the initially annotated noncoding RNA LINC00493 from human cells.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20941

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
small integral membrane protein 26
Names
long intergenic non-protein coding RNA 493

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348957.2 → NP_001335886.1  small integral membrane protein 26 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK024594
    Consensus CDS
    CCDS86936.1
    UniProtKB/Swiss-Prot
    A0A096LP01, A0A096LPB2
    Related
    ENSP00000485316.2, ENST00000411646.2

  2. NM_001348958.2 → NP_001335887.1  small integral membrane protein 26 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-terimi, but is one aa shorter than isoform 1.
    Source sequence(s)
    AL121900, BC092494, DR005796
    Consensus CDS
    CCDS86937.1
    Related
    ENSP00000485491.1, ENST00000435844.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    18567432..18569611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    18618488..18620664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_015432.1: Suppressed sequence

    Description
    NR_015432.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A096LP01.1 GenPept UniProtKB/Swiss-Prot:A0A096LP01

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials