U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG8209 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38888, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
CG8209provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035830
Locus tag
Dmel_CG8209
See related
AllianceGenome:FB:FBgn0035830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0172774.138; Dmel\CG8209
Summary
Predicted to enable K48-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein K48-linked deubiquitination; and negative regulation of protein ubiquitination. Located in cytoplasm and nucleus. Is expressed in several structures, including adult head; ganglia; germline cell; and gonad. Orthologous to human UBXN1 (UBX domain protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG8209 in Genome Data Viewer
Location:
66A21-66A21; 3-21 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7976406..7977849)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7969506..7970949)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ribonuclease X25 Neighboring gene uncharacterized protein Neighboring gene Heterochromatin protein 4 Neighboring gene POP4 ribonuclease P/MRP subunit Neighboring gene nemo Neighboring gene transfer RNA:Alanine-AGC 2-1 Neighboring gene antisense RNA:CR45867 Neighboring gene bip1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation. Schwendemann A, et al. Proc Natl Acad Sci U S A, 2008 Jan 8. PMID 18162556, Free PMC Article
  2. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. Beskow A, et al. J Mol Biol, 2009 Dec 11. PMID 19782090
  3. Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila. Bilen J, et al. PLoS Genet, 2007 Oct. PMID 17953484, Free PMC Article
  4. The deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagy. Pai YL, et al. Cell Death Dis, 2023 Aug 22. PMID 37607937, Free PMC Article
  5. Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10. Lee SY, et al. Cell Mol Life Sci, 2014 Jul. PMID 24292889, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables K48-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG8209-PA
UBA/UBX 33.3 kDa protein like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7976406..7977849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139910.4 → NP_648167.1  uncharacterized protein Dmel_CG8209 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648167.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYN6, Q9VSC5
    Related
    FBpp0076470
    Conserved Domains (2) summary
    cd01772
    Location:250 → 328
    SAKS1_UBX; SAKS1-like UBX domain
    cd14302
    Location:2 → 42
    UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SYN6 Q8SYN6
Q9VSC5 Q9VSC5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous