mus301 mutagen-sensitive 301 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mus301provided by FlyBase
Official Full Name: mutagen-sensitive 301provided by FlyBase
Primary source: FLYBASE:FBgn0002899
Locus tag: Dmel_CG7972
See related: AllianceGenome:FB:FBgn0002899
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.354; cg7972; CG7972; Dmel\CG7972; helq; mus(3)301; Mus301; spn-C; spnC; SpnC
Summary: Predicted to enable single-stranded 3'-5' DNA helicase activity. Involved in several processes, including female meiosis chromosome segregation; oogenesis; and specification of axis polarity. Orthologous to human HELQ (helicase, POLQ like). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8137808..8142014)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8130908..8135114)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

mus301 encodes a helicase with an essential role in ds DNA break repair and meiotic progression.
Title: Drosophila mus301/spindle-C encodes a helicase with an essential role in double-strand DNA break repair and meiotic progression.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded 3'-5' DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in double-strand break repair via synthesis-dependent strand annealing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female meiosis chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived oocyte fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germarium-derived oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular mRNA localization	TAS Traceable Author Statement more info	PubMed
involved_in oocyte karyosome formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oogenesis	TAS Traceable Author Statement more info	PubMed
involved_in polarity specification of anterior/posterior axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarity specification of dorsal/ventral axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	TAS Traceable Author Statement more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain