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Cpsf6 Cleavage and polyadenylation specific factor 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38937, updated on 9-Dec-2024

Summary

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Official Symbol
Cpsf6provided by FlyBase
Official Full Name
Cleavage and polyadenylation specific factor 6provided by FlyBase
Primary source
FLYBASE:FBgn0035872
Locus tag
Dmel_CG7185
See related
AllianceGenome:FB:FBgn0035872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CF I[[m]]68; CFI68; CFIm68; CFlm-68k; cg7185; CG7185; CPSF6; dCPSF6; Dmel\CG7185
Summary
Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut primordium; ganglia; and larval nervous system. Orthologous to human CPSF6 (cleavage and polyadenylation specific factor 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Cpsf6 in Genome Data Viewer
Location:
66C5-66C6; 3-24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8310493..8315502, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8303593..8308602, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 66a Neighboring gene long non-coding RNA:CR45409 Neighboring gene Bax Inhibitor-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SWI/SNF interacts with cleavage and polyadenylation factors and facilitates pre-mRNA 3' end processing. Yu S, et al. Nucleic Acids Res, 2018 Sep 19. PMID 29860334, Free PMC Article
  2. A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage. Gallicchio L, et al. Genes Dev, 2024 Aug 20. PMID 39111825,
  3. Positive selection in nucleoporins challenges constraints on early expressed genes in Drosophila development. Mensch J, et al. Genome Biol Evol, 2013. PMID 24171912, Free PMC Article
  4. Use of circular RNAs as markers of readthrough transcription to identify factors regulating cleavage/polyadenylation events. Liang D, et al. Methods, 2021 Dec. PMID 33882363, Free PMC Article
  5. Molecular Regulation of Alternative Polyadenylation (APA) within the Drosophila Nervous System. Vallejos Baier R, et al. J Mol Biol, 2017 Oct 27. PMID 28366829, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TORC1 signaling inhibits CDK8 and DOA kinases, which directly phosphorylate CPSF6, a component of the cleavage and polyadenylation (CPA) complex.
    Title: The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA alternative polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cleavage and polyadenylation specific factor 6
Names
CG7185-PA
CG7185-PB
Cpsf6-PA
Cpsf6-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8310493..8315502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259736.1 → NP_001246665.1  cleavage and polyadenylation specific factor 6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246665.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NF33
    Conserved Domains (1) summary
    cd12643
    Location:94 → 170
    RRM_CFIm68; RNA recognition motif of pre-mRNA cleavage factor Im 68 kDa subunit (CFIm68 or CPSF6) and similar proteins

  2. NM_139949.3 → NP_648206.1  cleavage and polyadenylation specific factor 6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648206.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TS9, Q9VSH4
    Related
    FBpp0076433
    Conserved Domains (1) summary
    cd12643
    Location:94 → 170
    RRM_CFIm68; RNA recognition motif of pre-mRNA cleavage factor Im 68 kDa subunit (CFIm68 or CPSF6) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NF33 M9NF33
Q9VSH4.2 Q9VSH4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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