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BNIP5 BCL2 interacting protein 5 [ Homo sapiens (human) ]

Gene ID: 389384, updated on 10-Dec-2024

Summary

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Official Symbol
BNIP5provided by HGNC
Official Full Name
BCL2 interacting protein 5provided by HGNC
Primary source
HGNC:HGNC:33769
See related
Ensembl:ENSG00000189325 AllianceGenome:HGNC:33769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf222
Expression
Biased expression in small intestine (RPKM 9.9), duodenum (RPKM 9.6) and 3 other tissues See more
Orthologs
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Genomic context

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See BNIP5 in Genome Data Viewer
Location:
6p21.31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36315761..36336888, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36136083..36157178, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36283538..36304665, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene BRPF3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24421 Neighboring gene bromodomain and PHD finger containing 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36203227-36203772 Neighboring gene Sharpr-MPRA regulatory region 10771 Neighboring gene uncharacterized LOC105375036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17111 Neighboring gene patatin like phospholipase domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36235945-36236531 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:36253718-36253903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36269917-36270417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36343773-36344272 Neighboring gene ETS variant transcription factor 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36354517-36355340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17114 Neighboring gene ETV7 and PTX1 antisense RNA 1 Neighboring gene peroxisomal testis enriched protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24427 Neighboring gene PXT1 intron CAGE-defined low expression enhancer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteins. DeBartolo J, et al. PLoS Comput Biol, 2014 Jun. PMID 24967846, Free PMC Article
  2. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • DKFZp779B1540

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
protein BNIP5
Names
uncharacterized protein C6orf222

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052656.1 RefSeqGene

    Range
    5128..26255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001010903.5 → NP_001010903.3  protein BNIP5

    See identical proteins and their annotated locations for NP_001010903.3

    Status: VALIDATED

    Source sequence(s)
    BC140873, BX648558, Z84484
    Consensus CDS
    CCDS34439.1
    UniProtKB/Swiss-Prot
    B2RTY8, P0C671
    Related
    ENSP00000418983.1, ENST00000437635.3
    Conserved Domains (1) summary
    pfam15661
    Location:14 → 652
    CF222; C6orf222, uncharacterized family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    36315761..36336888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514598.3 → XP_011512900.1  protein BNIP5 isoform X3

    Conserved Domains (1) summary
    pfam15661
    Location:1 → 404
    CF222; C6orf222, uncharacterized family

  2. XM_011514597.3 → XP_011512899.1  protein BNIP5 isoform X2

    Conserved Domains (1) summary
    pfam15661
    Location:14 → 651
    CF222; C6orf222, uncharacterized family

  3. XM_011514596.3 → XP_011512898.1  protein BNIP5 isoform X1

    See identical proteins and their annotated locations for XP_011512898.1

    UniProtKB/Swiss-Prot
    B2RTY8, P0C671
    Conserved Domains (1) summary
    pfam15661
    Location:14 → 652
    CF222; C6orf222, uncharacterized family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    36136083..36157178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355415.1 → XP_054211390.1  protein BNIP5 isoform X3

  2. XM_054355414.1 → XP_054211389.1  protein BNIP5 isoform X2

  3. XM_054355413.1 → XP_054211388.1  protein BNIP5 isoform X1

    UniProtKB/Swiss-Prot
    B2RTY8, P0C671
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C671.1 GenPept UniProtKB/Swiss-Prot:P0C671

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