Pex2 Peroxin 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pex2provided by FlyBase
Official Full Name: Peroxin 2provided by FlyBase
Primary source: FLYBASE:FBgn0035876
Locus tag: Dmel_CG7081
See related: AllianceGenome:FB:FBgn0035876
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7081; DmelPex2; Dmel\CG7081; pex2; PEX2
Summary: Predicted to enable protein transmembrane transporter activity; ubiquitin protein ligase activity; and zinc ion binding activity. Involved in protein import into peroxisome matrix. Located in peroxisome. Used to study peroxisomal disease and peroxisome biogenesis disorder 5A. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 5B and peroxisome biogenesis disorder 5A. Orthologous to human PEX2 (peroxisomal biogenesis factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8339051..8340276)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8332151..8333376)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein import into peroxisome matrix	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome matrix	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into peroxisome matrix, receptor recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain