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Cbl - Cbl proto-oncogene

Enables receptor tyrosine kinase binding activity and ubiquitin protein ligase activity. Involved in several processes, including germ cell development; negative regulation of signal transduction; and positive regulation of border follicle cell migration. Located in cell cortex. Is expressed in several structures, including Malpighian tubule; embryonic/larval hindgut; germarium; nurse cell; and ovary. Human ortholog(s) of this gene implicated in carcinoma (multiple); congestive heart failure; hematologic cancer (multiple); and type 1 diabetes mellitus. Orthologous to several human genes including CBL (Cbl proto-oncogene) and CBLB (Cbl proto-oncogene B). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Cbl

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Species Gene Architecture aa