se sepia [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: seprovided by FlyBase
Official Full Name: sepiaprovided by FlyBase
Primary source: FLYBASE:FBgn0086348
Locus tag: Dmel_CG6781
See related: AllianceGenome:FB:FBgn0086348
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cg6781; CG6781; Dmel\CG6781; dmgsto1; DmGSTO4; GSTO1; GSTO4; Sepia
Summary: Enables several functions, including glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; and protein homodimerization activity. Involved in eye pigment biosynthetic process; glutathione metabolic process; and pteridine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in adult head and eye. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 66D5-66D5; 3-26 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8520552..8521489)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8513652..8514589)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The isolation and charaterization of PDA synthase as the deficient enzyme underlying the sepia mutation in D. melanogaster is reported.
Title: Identification and characteristics of the structural gene for the Drosophila eye colour mutant sepia, encoding PDA synthase, a member of the omega class glutathione S-transferases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables glutathione dehydrogenase (ascorbate) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione dehydrogenase (ascorbate) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables pyrimidodiazepine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyrimidodiazepine synthase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables pyrimidodiazepine synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in eye pigment biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pteridine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sepia

Names: CG6781-PA; se-PA

NP_648235.1

EC 1.5.4.1

EC 1.8.5.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8520552..8521489

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_139978.4 → NP_648235.1 sepia [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648235.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D1KS67, D1KS72, Q9VSL3

Related

FBpp0076349

Conserved Domains (3) summary

cd03184
Location:109 → 229

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

COG0625
Location:22 → 215

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03055
Location:3 → 95

GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...