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Zasp66 Z band alternatively spliced PDZ-motif protein 66 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38988, updated on 4-Jan-2025

Summary

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Official Symbol
Zasp66provided by FlyBase
Official Full Name
Z band alternatively spliced PDZ-motif protein 66provided by FlyBase
Primary source
FLYBASE:FBgn0035917
Locus tag
Dmel_CG6416
See related
AllianceGenome:FB:FBgn0035917
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0153538.30; CG6416; Dmel\CG6416; Zaps66; ZASP66
Summary
Enables muscle alpha-actinin binding activity and protein phosphatase 1 binding activity. Involved in mesoderm development and myofibril assembly. Located in Z disc. Is expressed in adult head; adult heart; adult muscle cell; embryonic/larval midgut; and somatic muscle. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to several human genes including PDLIM1 (PDZ and LIM domain 1); PDLIM2 (PDZ and LIM domain 2); and PDLIM3 (PDZ and LIM domain 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Zasp66 in Genome Data Viewer
Location:
66D9-66D9; 3-26 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8624371..8638813)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8617471..8631913)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Sperm-Leucylaminopeptidase 1 Neighboring gene Sperm-Leucylaminopeptidase 2 Neighboring gene GTPase activating protein, SECIS-dependent read-through Neighboring gene Cell division cycle 6 Neighboring gene Cuticular protein 66D Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The unexpected versatility of ALP/Enigma family proteins. Fisher LAB, et al. Front Cell Dev Biol, 2022. PMID 36531944, Free PMC Article
  2. Drosophila melanogaster muscle LIM protein and alpha-actinin function together to stabilize muscle cytoarchitecture: a potential role for Mlp84B in actin-crosslinking. Clark KA, et al. Cytoskeleton (Hoboken), 2013 Jun. PMID 23606669, Free PMC Article
  3. Different Evolutionary Trajectories of Two Insect-Specific Paralogous Proteins Involved in Stabilizing Muscle Myofibrils. González-Morales N, et al. Genetics, 2019 Jul. PMID 31123042, Free PMC Article
  4. Nucleus-dependent sarcomere assembly is mediated by the LINC complex. Auld AL, et al. Mol Biol Cell, 2016 Aug 1. PMID 27307582, Free PMC Article
  5. Myofibril diameter is set by a finely tuned mechanism of protein oligomerization in Drosophila. González-Morales N, et al. Elife, 2019 Nov 20. PMID 31746737, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zasp66 null mutant has limited viability, but only mild indirect flight muscle defects.
    Title: Different Evolutionary Trajectories of Two Insect-Specific Paralogous Proteins Involved in Stabilizing Muscle Myofibrils.
  2. Zasp52 and Zasp66 directly bind to alpha-actinin, and they can also form a ternary complex.
    Title: Alp/Enigma family proteins cooperate in Z-disc formation and myofibril assembly.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables muscle alpha-actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables muscle alpha-actinin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase 1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mesoderm development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in muscle structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myofibril assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of filamentous actin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Z band alternatively spliced PDZ-motif protein 66
Names
CG6416-PA
CG6416-PB
CG6416-PE
CG6416-PF
CG6416-PG
CG6416-PH
CG6416-PI
CG6416-PJ
CG6416-PK
CG6416-PM
CG6416-PN
CG6416-PO
Zasp66-PA
Zasp66-PB
Zasp66-PE
Zasp66-PF
Zasp66-PG
Zasp66-PH
Zasp66-PI
Zasp66-PJ
Zasp66-PK
Zasp66-PM
Zasp66-PN
Zasp66-PO

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8624371..8638813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169914.3 → NP_001163385.1  Z band alternatively spliced PDZ-motif protein 66, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163385.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JI73
    Conserved Domains (2) summary
    cd00992
    Location:68 → 115
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:285 → 393
    DUF4749; Domain of unknown function (DUF4749)

  2. NM_168283.4 → NP_729395.2  Z band alternatively spliced PDZ-motif protein 66, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729395.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQB4
    Related
    FBpp0088529
    Conserved Domains (2) summary
    cd00992
    Location:68 → 115
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:285 → 359
    DUF4749; Domain of unknown function (DUF4749)

  3. NM_001169915.2 → NP_001163386.1  Z band alternatively spliced PDZ-motif protein 66, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163386.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JI74
    Conserved Domains (2) summary
    cd00992
    Location:68 → 115
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:285 → 314
    DUF4749; Domain of unknown function (DUF4749)

  4. NM_168284.3 → NP_729396.2  Z band alternatively spliced PDZ-motif protein 66, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729396.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQB3, Q95TZ7
    Related
    FBpp0088531
    Conserved Domains (2) summary
    cd00992
    Location:10 → 87
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:257 → 331
    DUF4749; Domain of unknown function (DUF4749)

  5. NM_001169913.1 → NP_001163384.1  Z band alternatively spliced PDZ-motif protein 66, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163384.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D6W4L4, E1JI76
    Conserved Domains (2) summary
    cd00992
    Location:10 → 87
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:257 → 314
    DUF4749; Domain of unknown function (DUF4749)

  6. NM_001169911.1 → NP_001163382.1  Z band alternatively spliced PDZ-motif protein 66, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163382.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q058U1
    Conserved Domains (2) summary
    cd00992
    Location:10 → 87
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:257 → 365
    DUF4749; Domain of unknown function (DUF4749)

  7. NM_139989.4 → NP_648246.3  Z band alternatively spliced PDZ-motif protein 66, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648246.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    D6W4L4, Q7KUB5
    Conserved Domains (2) summary
    cd00992
    Location:10 → 87
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:257 → 286
    DUF4749; Domain of unknown function (DUF4749)

  8. NM_176303.5 → NP_788481.1  Z band alternatively spliced PDZ-motif protein 66, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788481.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BH6
    Related
    FBpp0088534
    Conserved Domains (1) summary
    pfam15936
    Location:94 → 158
    DUF4749; Domain of unknown function (DUF4749)

  9. NM_176304.5 → NP_788482.1  Z band alternatively spliced PDZ-motif protein 66, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788482.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BH5
    Related
    FBpp0088533
    Conserved Domains (1) summary
    pfam15936
    Location:94 → 123
    DUF4749; Domain of unknown function (DUF4749)

  10. NM_176306.3 → NP_788484.2  Z band alternatively spliced PDZ-motif protein 66, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788484.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSN2
    Related
    FBpp0088535
    Conserved Domains (1) summary
    pfam15936
    Location:94 → 182
    DUF4749; Domain of unknown function (DUF4749)

  11. NM_168286.4 → NP_729398.1  Z band alternatively spliced PDZ-motif protein 66, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729398.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSN2
    Related
    FBpp0088530
    Conserved Domains (1) summary
    pfam15936
    Location:94 → 182
    DUF4749; Domain of unknown function (DUF4749)

  12. NM_176305.4 → NP_788483.1  Z band alternatively spliced PDZ-motif protein 66, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788483.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSN0
    Related
    FBpp0088532
    Conserved Domains (1) summary
    pfam15936
    Location:94 → 121
    DUF4749; Domain of unknown function (DUF4749)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JI73 E1JI73
E1JI74 E1JI74
E1JI76 E1JI76
Q058U1 Q058U1
Q7KUB5 Q7KUB5
Q86BH5 Q86BH5
Q86BH6 Q86BH6
Q8IQB4 Q8IQB4
Q95S47 Q95S47
Q95TZ7 Q95TZ7
Q9VSN0 Q9VSN0
Q9VSN2 Q9VSN2

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