Prm Paramyosin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prmprovided by FlyBase
Official Full Name: Paramyosinprovided by FlyBase
Primary source: FLYBASE:FBgn0003149
Locus tag: Dmel_CG5939
See related: AllianceGenome:FB:FBgn0003149
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0106/05; CG5939; Dmel\CG5939; l(3)10631; l(3)S010605; mPM; Para; pm; PM; PM/mPM; prm
Summary: Predicted to enable Rho-dependent protein serine/threonine kinase activity. Involved in mesoderm development and myofibril assembly. Located in M band and striated muscle myosin thick filament. Is expressed in adult head and adult heart. Orthologous to human MYH16 (myosin heavy chain 16). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8732858..8745310, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8725958..8738410, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Paramyosin phosphorylation site disruption affects indirect flight muscle stiffness and power generation in Drosophila melanogaster.
Title: Paramyosin phosphorylation site disruption affects indirect flight muscle stiffness and power generation in Drosophila melanogaster.
Overexpression of miniparamyosin causes muscle dysfunction and age-dependant myofibril degeneration in the indirect flight muscles of Drosophila melanogaster.
Title: Overexpression of miniparamyosin causes muscle dysfunction and age-dependant myofibril degeneration in the indirect flight muscles of Drosophila melanogaster.
expression from the Drosophila Paramyosin/miniparamyosin gene is regulated by enhancer elements in different muscle types
Title: Co-operation between enhancers modulates quantitative expression from the Drosophila Paramyosin/miniparamyosin gene in different muscle types.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables Rho-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mesoderm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in M band	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in striated muscle myosin thick filament	HDA more info	PubMed

Names: CG5939-PA; CG5939-PB; CG5939-PC; CG5939-PD; CG5939-PE; Prm-PA; Prm-PB; Prm-PC; Prm-PD; Prm-PE; lethal (3) S010605; miniparamyosin; paramyosin/miniparamyosin