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Tsp66E Tetraspanin 66E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39017, updated on 9-Dec-2024

Summary

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Official Symbol
Tsp66Eprovided by FlyBase
Official Full Name
Tetraspanin 66Eprovided by FlyBase
Primary source
FLYBASE:FBgn0035936
Locus tag
Dmel_CG4999
See related
AllianceGenome:FB:FBgn0035936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4999; Dm.Tsp66E; Dmel\CG4999; tsp66E
Summary
Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; egg chamber; embryonic anal pad; and gut section. Orthologous to human CD37 (CD37 molecule) and CD82 (CD82 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Tsp66E in Genome Data Viewer
Location:
66E3-66E4; 3-27 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8912499..8932065)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8905599..8925165)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45871 Neighboring gene transfer RNA:Threonine-AGT 3-1 pseudogene Neighboring gene Minichromosome maintenance 7 Neighboring gene Transient receptor potential cation channel A1 Neighboring gene long non-coding RNA:CR43970 Neighboring gene misfire Neighboring gene uncharacterized protein Neighboring gene orb2 Neighboring gene Gram-negative bacteria binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization. Han SY, et al. FEBS Lett, 2012 Nov 16. PMID 23068610
  2. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
  3. Integrating GWAS and Transcriptomics to Identify the Molecular Underpinnings of Thermal Stress Responses in Drosophila melanogaster. Lecheta MC, et al. Front Genet, 2020. PMID 32655626, Free PMC Article
  4. Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc. González-Méndez L, et al. EMBO J, 2020 Jun 2. PMID 32311148, Free PMC Article
  5. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that Tsp66E and Tsp74F mutant ovaries had elevated inflated gene product alphaPS2 integrin levels and reduced endocytic trafficking.
    Title: Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetraspanin 66E
Names
CG4999-PA
CG4999-PB
CG4999-PC
Tsp66E-PA
Tsp66E-PB
Tsp66E-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8912499..8932065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168298.1 → NP_729423.1  tetraspanin 66E, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729423.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3E5
    Related
    FBpp0076233, FBtr0076506
    Conserved Domains (2) summary
    cd03156
    Location:116 → 231
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9 → 258
    Tetraspannin; Tetraspanin family

  2. NM_168299.2 → NP_729424.1  tetraspanin 66E, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729424.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3E5
    Related
    FBpp0076235
    Conserved Domains (2) summary
    cd03156
    Location:116 → 231
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9 → 258
    Tetraspannin; Tetraspanin family

  3. NM_079261.5 → NP_523985.1  tetraspanin 66E, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523985.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3E5
    Related
    FBpp0076234
    Conserved Domains (2) summary
    cd03156
    Location:116 → 231
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9 → 258
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3E5 Q9V3E5

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