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CG5026 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39026, updated on 9-Dec-2024

Summary

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Official Symbol
CG5026provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035945
Locus tag
Dmel_CG5026
See related
AllianceGenome:FB:FBgn0035945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5026; MTMR9
Summary
Predicted to enable protein phosphatase binding activity. Predicted to be involved in negative regulation of autophagy and phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm. Orthologous to human MTMR9 (myotubularin related protein 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG5026 in Genome Data Viewer
Location:
66E5-66E6; 3-27 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8968528..8971752)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8961628..8964852)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pixie Neighboring gene Signal recognition particle 68 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myotubularin phosphatases: policing 3-phosphoinositides. Robinson FL, et al. Trends Cell Biol, 2006 Aug. PMID 16828287
  2. Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability. Kleefstra T, et al. Am J Hum Genet, 2012 Jul 13. PMID 22726846, Free PMC Article
  3. Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. Jean S, et al. Mol Biol Cell, 2012 Jul. PMID 22648168, Free PMC Article
  4. Genome-wide assessment of AU-rich elements by the AREScore algorithm. Spasic M, et al. PLoS Genet, 2012 Jan. PMID 22242014, Free PMC Article
  5. Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2. Lu J, et al. Elife, 2022 Jun 9. PMID 35678383, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables phosphatase activity IKR
Inferred from Key Residues
more info
 PubMed 
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables protein tyrosine phosphatase activity IKR
Inferred from Key Residues
more info
 PubMed 
NOT enables protein tyrosine/serine/threonine phosphatase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5026-PA
CG5026-PB
CG5026-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8968528..8971752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140014.4 → NP_648271.3  uncharacterized protein Dmel_CG5026, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648271.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZY7, Q9VSS0
    Conserved Domains (2) summary
    cd13211
    Location:1 → 106
    PH-GRAM_MTMR9; Myotubularian (MTM) related 9 protein (MTMR9) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam06602
    Location:117 → 511
    Myotub-related; Myotubularin-like phosphatase domain

  2. NM_168305.4 → NP_729434.2  uncharacterized protein Dmel_CG5026, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729434.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZY7, Q9VSS0
    Conserved Domains (2) summary
    cd13211
    Location:1 → 106
    PH-GRAM_MTMR9; Myotubularian (MTM) related 9 protein (MTMR9) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam06602
    Location:117 → 511
    Myotub-related; Myotubularin-like phosphatase domain

  3. NM_001169921.2 → NP_001163392.1  uncharacterized protein Dmel_CG5026, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163392.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZY7, Q9VSS0
    Conserved Domains (2) summary
    cd13211
    Location:1 → 106
    PH-GRAM_MTMR9; Myotubularian (MTM) related 9 protein (MTMR9) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam06602
    Location:117 → 511
    Myotub-related; Myotubularin-like phosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRD6 Q8MRD6
Q8SZY7 Q8SZY7

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