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Dhpr Dihydropteridine reductase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39050, updated on 9-Dec-2024

Summary

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Official Symbol
Dhprprovided by FlyBase
Official Full Name
Dihydropteridine reductaseprovided by FlyBase
Primary source
FLYBASE:FBgn0035964
Locus tag
Dmel_CG4665
See related
AllianceGenome:FB:FBgn0035964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4665; DHPR; Dmel\CG4665
Summary
Predicted to enable 6,7-dihydropteridine reductase activity; NADH binding activity; and NADPH binding activity. Predicted to be involved in L-phenylalanine catabolic process and tetrahydrobiopterin biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; embryonic/larval midgut primordium; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia C and phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Dhpr in Genome Data Viewer
Location:
67A1-67A1; 3-28 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9134560..9135916)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9127660..9129016)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene boule Neighboring gene Unconventional SNARE in the ER 1 Neighboring gene nervous wreck Neighboring gene mir-4940 stem loop Neighboring gene Resistant to dieldrin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular characterization of Drosophila melanogaster dihydropteridine reductase. Park D, et al. Biochim Biophys Acta, 2000 Jun 21. PMID 11004497
  2. Comparison of inter- and intraspecies variation in humans and fruit flies. Shih J, et al. Genom Data, 2015 Mar. PMID 26484147, Free PMC Article
  3. graal: a Drosophila gene coding for several mosaic serine proteases. Munier AI, et al. Insect Biochem Mol Biol, 2004 Oct. PMID 15475297
  4. Retrotransposon-gene associations are widespread among D. melanogaster populations. Franchini LF, et al. Mol Biol Evol, 2004 Jul. PMID 15014149
  5. Studies on the glutathione S-transferase proteome of adult Drosophila melanogaster: responsiveness to chemical challenge. Alias Z, et al. Proteomics, 2007 Oct. PMID 17907271

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dhpr regulates mitochondrial morphology and tissue homeostasis by modulating S-nitrosylation of Drp1.
    Title: Large-scale RNAi screen identified Dhpr as a regulator of mitochondrial morphology and tissue homeostasis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 6,7-dihydropteridine reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADH binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADPH binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrahydrobiopterin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dihydropteridine reductase
Names
CG4665-PA
CG4665-PB
CG4665-PC
Dhpr-PA
Dhpr-PB
Dhpr-PC
NP_001014579.1
NP_001014580.1
NP_523990.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9134560..9135916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079266.5 → NP_523990.1  dihydropteridine reductase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523990.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSU6
    Related
    FBpp0076258
    Conserved Domains (2) summary
    cd05334
    Location:3 → 224
    DHPR_SDR_c_like; dihydropteridine reductase (DHPR), classical (c) SDRs
    pfam00106
    Location:6 → 188
    adh_short; short chain dehydrogenase

  2. NM_001014580.3 → NP_001014580.1  dihydropteridine reductase, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSU6
    Conserved Domains (2) summary
    cd05334
    Location:3 → 224
    DHPR_SDR_c_like; dihydropteridine reductase (DHPR), classical (c) SDRs
    pfam00106
    Location:6 → 188
    adh_short; short chain dehydrogenase

  3. NM_001014579.2 → NP_001014579.1  dihydropteridine reductase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014579.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSU6
    Conserved Domains (2) summary
    cd05334
    Location:3 → 224
    DHPR_SDR_c_like; dihydropteridine reductase (DHPR), classical (c) SDRs
    pfam00106
    Location:6 → 188
    adh_short; short chain dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VSU6 Q9VSU6

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