Fdx1 Ferredoxin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fdx1provided by FlyBase
Official Full Name: Ferredoxin 1provided by FlyBase
Primary source: FLYBASE:FBgn0011769
Locus tag: Dmel_CG4205
See related: AllianceGenome:FB:FBgn0011769
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RH67819; CG4205; Dmel\CG4205; Fdxh
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity and electron transfer activity. Involved in positive regulation of ecdysteroid biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in wing hinge primordium and wing pouch. Human ortholog(s) of this gene implicated in mitochondrial myopathy. Orthologous to human FDX2 (ferredoxin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9370195..9371238, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9363295..9364338, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables electron transfer activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in P450-containing electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in electron transport chain	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of ecdysteroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial matrix	NAS Non-traceable Author Statement more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain