Hsp67Bc Heat shock gene 67Bc [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsp67Bcprovided by FlyBase
Official Full Name: Heat shock gene 67Bcprovided by FlyBase
Primary source: FLYBASE:FBgn0001229
Locus tag: Dmel_CG4190
See related: AllianceGenome:FB:FBgn0001229
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4190; Dm-HSP67Bc; Dmel18.0; Dmel\CG4190; gene 3; gene-3; gene3; gene5; Hsp-G3; HSP67; hsp67B; hsp67bc; hsp67Bc; Hsp67BC; HSP67Bc; HSP67BC; HspB8; HSPB8; Hspg3; small hsp locus 67B
Summary: Predicted to enable unfolded protein binding activity. Involved in regulation of autophagy; regulation of protein metabolic process; and response to heat. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including embryonic head sensory system; ganglia; sensory nervous system primordium; and yolk nucleus. Used to study Charcot-Marie-Tooth disease axonal type 2L and autosomal dominant distal hereditary motor neuronopathy 2. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to human CRYAA (crystallin alpha A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 67B2-67B2; 3-29 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9371511..9372497, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9364611..9365597, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Hsp67Bc leads to autolysosome enlargement in the Drosophila brain.
Title: Loss of Hsp67Bc leads to autolysosome enlargement in the Drosophila brain.
Small heat shock protein Hsp67Bc plays a significant role in Drosophila melanogaster cold stress tolerance.
Title: Small heat shock protein Hsp67Bc plays a significant role in Drosophila melanogaster cold stress tolerance.
Heat shock gene 67Bc (Hsp67Bc) is present at neuromuscular junctions (NMJs), which implies its involvement in the maintenance of NMJ structure.
Title: Drosophila Hsp67Bc hot-spot variants alter muscle structure and function.
In this review, we represent and discuss data on the role of Drosophila melanogaster Hsp67Bc protein, which was earlier identified as the closest functional ortholog of human HSPB8 small heat shock protein.
Title: THE FUNCTIONAL ROLE OF SMALL HEAT SHOCK PROTEIN Hsp67Bc IN DROSOPHILA MELANOGASTER.
We report that overexpression of HSPB8 in immortalized motor neurones decreased the accumulation of TDP-25 and TDP-35 and that protection against mislocalized/truncated TDP-43 was observed for HSPB8 in Drosophila melanogaster Overexpression of HSP67Bc, the functional ortholog of human HSPB8, suppressed the eye degeneration caused by the cytoplasmic accumulation of a TDP-43 variant
Title: The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.
Drosophila HSP67Bc is the functional ortholog of human HSPB8 and Dm-HSP67Bc induces autophagy via the eIF2alpha pathway.
Title: Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0947 (e-PCR)
- UniSTS:16609

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein folding	ISM Inferred from Sequence Model more info	PubMed
involved_in positive regulation of protein lipidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock gene 67Bc

Names: CG4190-PA; Hsp67Bc-PA; gene 3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9371511..9372497 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079270.3 → NP_523994.1 heat shock gene 67Bc [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523994.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P22979, Q4V3R7, Q9VSW9

Related

FBpp0076225

Conserved Domains (2) summary

cd06526
Location:75 → 154

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...

COG0071
Location:79 → 170

IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]