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Nf-YA Nuclear factor Y-box A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39091, updated on 9-Dec-2024

Summary

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Official Symbol
Nf-YAprovided by FlyBase
Official Full Name
Nuclear factor Y-box Aprovided by FlyBase
Primary source
FLYBASE:FBgn0035993
Locus tag
Dmel_CG3891
See related
AllianceGenome:FB:FBgn0035993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3891; Dmel\CG3891; dNF-YA; NF-YA
Summary
Enables transcription cis-regulatory region binding activity. Contributes to sequence-specific DNA binding activity. Involved in R7 cell differentiation and positive regulation of DNA-templated transcription. Part of CCAAT-binding activity factor complex. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Orthologous to human NFYA (nuclear transcription factor Y subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Nf-YA in Genome Data Viewer
Location:
67B6-67B6; 3-29 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9440056..9442267, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9433156..9435367, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Metal response element-binding Transcription Factor-1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45872 Neighboring gene Blocked early in transport 3 Neighboring gene Sting-regulated gene 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NF-Y transcriptionally regulates the Drosophila p53 gene. Tue NT, et al. Gene, 2011 Feb 15. PMID 21044877
  2. Drosophila transcription factor NF-Y suppresses transcription of the lipase 4 gene, a key gene for lipid storage. Yoshioka Y, et al. Exp Cell Res, 2022 Nov 1. PMID 36028059
  3. Transcription factor NF-Y is involved in regulation of the JNK pathway during Drosophila thorax development. Yoshioka Y, et al. Genes Cells, 2008 Feb. PMID 18233955
  4. Transcription factor NF-Y is involved in differentiation of R7 photoreceptor cell in Drosophila. Yoshioka Y, et al. Biol Open, 2012 Jan 15. PMID 23213364, Free PMC Article
  5. Preservation of ∼12-h ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock. Zhu B, et al. Front Physiol, 2023. PMID 37324401, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in R7 cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CCAAT-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCAAT-binding factor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nuclear factor Y-box A
Names
CG3891-PA
Nf-YA-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9440056..9442267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140056.3 → NP_648313.1  nuclear factor Y-box A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648313.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSY9
    Related
    FBpp0076232
    Conserved Domains (1) summary
    smart00521
    Location:286 → 345
    CBF; CCAAT-Binding transcription Factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VSY9 Q9VSY9

Gene LinkOut

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