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Srg3 Sting-regulated gene 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39092, updated on 9-Dec-2024

Summary

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Official Symbol
Srg3provided by FlyBase
Official Full Name
Sting-regulated gene 3provided by FlyBase
Primary source
FLYBASE:FBgn0053926
Locus tag
Dmel_CG33926
See related
AllianceGenome:FB:FBgn0053926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33926; Dmel\CG33926; srg3
Summary
Involved in defense response to virus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Srg3 in Genome Data Viewer
Location:
67B6-67B7; 3-29 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9443232..9446388)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9436332..9439488)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Metal response element-binding Transcription Factor-1 Neighboring gene antisense RNA:CR45872 Neighboring gene Blocked early in transport 3 Neighboring gene Nuclear factor Y-box A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ghiberti

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila. Slavik KM, et al. Nature, 2021 Sep. PMID 34261127, Free PMC Article
  2. Two cGAS-like receptors induce antiviral immunity in Drosophila. Holleufer A, et al. Nature, 2021 Sep. PMID 34261128
  3. 2'3'-cGAMP triggers a STING- and NF-κB-dependent broad antiviral response in Drosophila. Cai H, et al. Sci Signal, 2020 Dec 1. PMID 33262294
  4. A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock. Moskalev A, et al. BMC Genomics, 2015. PMID 26694630, Free PMC Article
  5. The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila. Goto A, et al. Immunity, 2018 Aug 21. PMID 30119996, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Sting-regulated gene 3
Names
CG33926-PA
CG33926-PB
Srg3-PA
Srg3-PB
sting-regulated gene 3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9443232..9446388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300075.1 → NP_001287004.1  Sting-regulated gene 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287004.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V5R6, Q9VSZ0
    Conserved Domains (1) summary
    PHA02596
    Location:52 → 176
    5; baseplate hub subunit and tail lysozyme; Provisional

  2. NM_001031947.3 → NP_001027118.1  Sting-regulated gene 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027118.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V5R6, Q9VSZ0
    Conserved Domains (1) summary
    PHA02596
    Location:52 → 176
    5; baseplate hub subunit and tail lysozyme; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VSZ0 Q9VSZ0

Gene LinkOut

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