Zasp67 Z band alternatively spliced PDZ-motif protein 67 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Zasp67provided by FlyBase
Official Full Name: Z band alternatively spliced PDZ-motif protein 67provided by FlyBase
Primary source: FLYBASE:FBgn0036044
Locus tag: Dmel_CG14168
See related: AllianceGenome:FB:FBgn0036044
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14168; Dmel\CG14168
Summary: Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Involved in myofibril assembly. Predicted to be part of filamentous actin. Predicted to be active in Z disc; adherens junction; and stress fiber. Is expressed in indirect flight muscle cell. Orthologous to human PDLIM2 (PDZ and LIM domain 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 67C8-67C8; 3-31 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9787933..9797687, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9781033..9790787, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zasp67 null mutant is viable but flightless. Zasp67 mutants show extended and broken Z-discs in adult flies.
Title: Different Evolutionary Trajectories of Two Insect-Specific Paralogous Proteins Involved in Stabilizing Muscle Myofibrils.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables muscle alpha-actinin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle structure development	IBA Inferred from Biological aspect of Ancestor more info
involved_in myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
part_of filamentous actin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Z band alternatively spliced PDZ-motif protein 67

Names: CG14168-PD; CG14168-PE; CG14168-PG; CG14168-PH; PDZ and LIM domain protein zasp; Zasp67-PD; Zasp67-PE; Zasp67-PG; Zasp67-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9787933..9797687 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274726.1 → NP_001261655.1 Z band alternatively spliced PDZ-motif protein 67, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261655.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEZ7

Conserved Domains (2) summary

cd00992
Location:2 → 75

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:648 → 694

DUF4749; Domain of unknown function (DUF4749)
NM_001300086.1 → NP_001287015.1 Z band alternatively spliced PDZ-motif protein 67, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287015.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JGI5

Conserved Domains (1) summary

cd00992
Location:2 → 75

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_140101.2 → NP_648358.2 Z band alternatively spliced PDZ-motif protein 67, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648358.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VT49

Conserved Domains (2) summary

cd00992
Location:2 → 75

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:653 → 699

DUF4749; Domain of unknown function (DUF4749)
NM_001274725.1 → NP_001261654.1 Z band alternatively spliced PDZ-motif protein 67, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261654.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PF54

Conserved Domains (1) summary

cd00992
Location:2 → 75

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...