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Ilp1 Insulin-like peptide 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39149, updated on 9-Dec-2024

Summary

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Official Symbol
Ilp1provided by FlyBase
Official Full Name
Insulin-like peptide 1provided by FlyBase
Primary source
FLYBASE:FBgn0044051
Locus tag
Dmel_CG14173
See related
AllianceGenome:FB:FBgn0044051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14173; dilp; dILP; Dilp; DILP; Dilp 1; DILP 1; dilp-1; Dilp-1; DILP-1; dilp1; dILP1; Dilp1; DILP1; Dilp1-5; DILPs; dlp; Dmel\CG14173; Ilp; Ilp-1; ilp1; ILP1; ILPs
Summary
Predicted to enable insulin receptor binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be located in extracellular space. Is expressed in several structures, including insulin secreting cell of pars intercerebralis; larval brain; larval pars intercerebralis; and pars intercerebralis primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ilp1 in Genome Data Viewer
Location:
67C8-67C8; 3-31 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9798420..9799050)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9791534..9791998)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Anion exchanger 2 Neighboring gene uncharacterized protein Neighboring gene Z band alternatively spliced PDZ-motif protein 67 Neighboring gene Insulin-like peptide 2 Neighboring gene Insulin-like peptide 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Making Feeding Decisions in the Drosophila Nervous System. Miroschnikow A, et al. Curr Biol, 2020 Jul 20. PMID 32693083
  2. Processed short neuropeptide F peptides regulate growth through the ERK-insulin pathway in Drosophila melanogaster. Lee KS, et al. FEBS Lett, 2009 Aug 6. PMID 19619547
  3. The Drosophila retained/dead ringer gene and ARID gene family function during development. Shandala T, et al. Int J Dev Biol, 2002. PMID 12141428
  4. Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signaling. Ostojic I, et al. Proc Natl Acad Sci U S A, 2014 Jun 3. PMID 24847072, Free PMC Article
  5. Altered sperm fate in the reproductive tract milieu due to oxidative stress leads to sub-fertility in type 1 diabetes females: A Drosophila-based study. Gupta HP, et al. Life Sci, 2023 Jan 15. PMID 36543282

See all (148) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dilp2 modulates lifespan in part by regulating Akh, and by repressing dilp1, which acts as a pro-longevity insulin-like peptide.
    Title: Drosophila insulin-like peptide dilp1 increases lifespan and glucagon-like Akh expression epistatic to dilp2.
  2. DILP1 is expressed in non-feeding stages and in diapausing flies, is under feedback regulation and appears to play sex-specific functional roles.
    Title: Drosophila insulin-like peptide 1 (DILP1) is transiently expressed during non-feeding stages and reproductive dormancy.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables insulin receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Insulin-like peptide 1
Names
CG14173-PA
Ilp1-PA
drosophila insulin-like peptide
drosophila insulin-like peptide 1
insulin-like peptide
insulin/insulin-like growth factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9798420..9799050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140102.2 → NP_648359.1  Insulin-like peptide 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648359.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VT50
    UniProtKB/TrEMBL
    C9QPG9, E7BBS0
    Related
    FBpp0076057
    Conserved Domains (1) summary
    cd04366
    Location:131 → 151
    IlGF_insulin_bombyxin_like; IlGF_like family, insulin_bombyxin_like subgroup. Members include a number of peptides including insulin, insulin-like growth factors I and II, insect prothoracicotropic hormone (bombyxin), locust insulin-related peptide (LIRP), molluscan insulin-related ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VT50.1 Q9VT50

Gene LinkOut

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