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Ilp3 Insulin-like peptide 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39151, updated on 9-Dec-2024

Summary

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Official Symbol
Ilp3provided by FlyBase
Official Full Name
Insulin-like peptide 3provided by FlyBase
Primary source
FLYBASE:FBgn0044050
Locus tag
Dmel_CG14167
See related
AllianceGenome:FB:FBgn0044050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14167; dilp; Dilp; DILP; dilp 3; Dilp 3; DILP 3; dilp-3; dILP-3; Dilp-3; DILP-3; Dilp1-5; dilp3; dIlp3; dILp3; dILP3; Dilp3; DILP3; DILPs; dipl3; dlp; dlp3; Dmel\CG14167; Ilp; Ilp-3; ilp3; IlP3; ILP3; ILPs
Summary
Predicted to enable insulin receptor binding activity. Involved in several processes, including insulin receptor signaling pathway; locomotor rhythm; and negative regulation of entry into reproductive diapause. Located in extracellular space. Is expressed in several structures, including adult midgut circular muscle cell; gastric caecum; gut section; insulin secreting cell of pars intercerebralis; and larval brain. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ilp3 in Genome Data Viewer
Location:
67C8-67C8; 3-31 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9801298..9802120, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9794398..9795220, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Insulin-like peptide 1 Neighboring gene Insulin-like peptide 2 Neighboring gene Insulin-like peptide 4 Neighboring gene uncharacterized protein Neighboring gene Insulin-like peptide 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ablation of insulin-producing cells prevents obesity but not premature mortality caused by a high-sugar diet in Drosophila. Al Saud SN, et al. Proc Biol Sci, 2015 Feb 7. PMID 25520354, Free PMC Article
  2. Cell biology. Insulin finds its niche. Cheetham SW, et al. Science, 2013 May 17. PMID 23687033
  3. Glut1 Functions in Insulin-Producing Neurons to Regulate Lipid and Carbohydrate Storage in Drosophila. Kauffman MR, et al. Biomolecules, 2024 Aug 20. PMID 39199423, Free PMC Article
  4. Solanum anguivi Lam. fruit preparations counteract the negative effects of a high-sugar diet on the glucose metabolism in Drosophila melanogaster. Nakitto AMS, et al. Food Funct, 2021 Oct 4. PMID 34606536
  5. A triple drug combination targeting components of the nutrient-sensing network maximizes longevity. Castillo-Quan JI, et al. Proc Natl Acad Sci U S A, 2019 Oct 15. PMID 31570569, Free PMC Article

See all (421) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Using two long-lived IIS models, namely Drosophila lacking three insulin-like peptides (dilp2-3,5(-/-)) and mice lacking insulin receptor substrate 1 (Irs1(-/-)), and two independent translation assays, polysome profiling and radiolabeled amino acid incorporation, we show that reduced IIS lowers translation in these organisms
    Title: Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice.
  2. Results found that virgin females with knockout mutations of Ilp2, Ilp3 and Ilp5 show high mating success rate with higher locomotion.
    Title: Knockout mutations of insulin-like peptide genes enhance sexual receptivity in Drosophila virgin females.
  3. Dilp3 is uniquely required for the sugar-mediated activation of TOR signalling and suppression of autophagy in the larval fat body.
    Title: Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3.
  4. show that the DILP-producing median neurosecretory cells are required to mediate nearly all of the response of lifespan and some of the response of fecundity to yeast levels
    Title: DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables insulin receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of entry into reproductive diapause IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to carbohydrate IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Insulin-like peptide 3
Names
CG14167-PA
Ilp3-PA
Insulin-like peptide
drosophila insulin-like peptide 3
insulin/insulin-like growth factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9801298..9802120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140103.3 → NP_648360.2  Insulin-like peptide 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648360.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VT52
    UniProtKB/TrEMBL
    E7BBS2, Q4V6A0
    Conserved Domains (1) summary
    cd04366
    Location:33 → 114
    IlGF_insulin_bombyxin_like; IlGF_like family, insulin_bombyxin_like subgroup. Members include a number of peptides including insulin, insulin-like growth factors I and II, insect prothoracicotropic hormone (bombyxin), locust insulin-related peptide (LIRP), molluscan insulin-related ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VT52.2 Q9VT52

Gene LinkOut

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