Rbfox1 RNA-binding Fox protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rbfox1provided by FlyBase
Official Full Name: RNA-binding Fox protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0052062
Locus tag: Dmel_CG32062
See related: AllianceGenome:FB:FBgn0052062
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A2bp1; A2BP1; BcDNA:GM06073; CG14155; cg18441; CG18441; CG32062; dA2BP1; Dmel\CG32062; rbfox1; Rbox1
Summary: Enables DNA-binding transcription factor binding activity; mRNA 3'-UTR binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including germarium-derived oocyte differentiation; imaginal disc-derived wing vein specification; and regulation of gene expression. Located in nuclear lumen and ribonucleoprotein granule. Is expressed in several structures, including developmental compartment; epithelium; imaginal disc; muscle cell; and somatic precursor cell. Used to study intellectual disability. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RBFOX1 (RNA binding fox-1 homolog 1); RBFOX2 (RNA binding fox-1 homolog 2); and RBFOX3 (RNA binding fox-1 homolog 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 67E4-67E5; 3-33 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (10481412..10594012)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (10474512..10587112)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rbfox1 is required for myofibril development and maintaining fiber type-specific isoform expression in Drosophila muscles.
Title: Rbfox1 is required for myofibril development and maintaining fiber type-specific isoform expression in Drosophila muscles.
Stress-dependent miR-980 regulation of Rbfox1/A2bp1 promotes ribonucleoprotein granule formation and cell survival.
Title: Stress-dependent miR-980 regulation of Rbfox1/A2bp1 promotes ribonucleoprotein granule formation and cell survival.
biochemical analysis shows that A2BP1 is part of the Suppressor of Hairless [Su(H)] complex in the presence and absence of Notch
Title: Ataxin 2-binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis in Drosophila melanogaster.
results reveal that cytoplasmic Rbfox family members regulate the translation of specific target mRNAs. In the Drosophila ovary
Title: Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation.
The results indicate that miR-980 represses the autism-susceptibility gene A2bp1expression to tune the excitable state of neurons, and the overall state of excitability translates to memory impairment or improvement.
Title: MiR-980 Is a Memory Suppressor MicroRNA that Regulates the Autism-Susceptibility Gene A2bp1.
Study reports that CG32062, the Drosophila homologue of Ataxin-2 Binding Protein 1 (dA2BP1), functions as a cofactor of Ci to specify intervein region between L3 and L4 veins of the adult wing.
Title: Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila.
In wing discs, expressed only in non-D/V cells. Negatively regulated during haltere specification.
Title: Identification of a novel target of D/V signaling in Drosophila wing disc: Wg-independent function of the organizer.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to chemical stress	IDA Inferred from Direct Assay more info	PubMed
involved_in germarium-derived oocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Cajal body	IDA Inferred from Direct Assay more info	PubMed
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RNA-binding Fox protein 1

Names: Ataxin-2 binding protein 1; CG32062-PE; CG32062-PF; CG32062-PH; CG32062-PI; CG32062-PJ; CG32062-PK; CG32062-PL; CG32062-PM; CG32062-PN; Rbfox1-PE; Rbfox1-PF; Rbfox1-PH; Rbfox1-PI; Rbfox1-PJ; Rbfox1-PK; Rbfox1-PL; Rbfox1-PM; Rbfox1-PN; ataxin 2-binding protein 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

10481412..10594012

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259778.1 → NP_001246707.1 RNA-binding Fox protein 1, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246707.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NFQ7

Conserved Domains (2) summary

COG0724
Location:454 → 542

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12407
Location:460 → 535

RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
NM_001259779.1 → NP_001246708.1 RNA-binding Fox protein 1, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246708.1

Status: REVIEWED

UniProtKB/TrEMBL

M9ND74

Conserved Domains (2) summary

COG0724
Location:388 → 476

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12407
Location:394 → 469

RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
NM_168412.4 → NP_729614.2 RNA-binding Fox protein 1, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729614.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VT99

Conserved Domains (2) summary

COG0724
Location:437 → 525

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12407
Location:443 → 518

RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
NM_001274751.1 → NP_001261680.1 RNA-binding Fox protein 1, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261680.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PF74

Conserved Domains (2) summary

COG0724
Location:212 → 300

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12407
Location:218 → 293

RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
NM_168413.3 → NP_729615.2 RNA-binding Fox protein 1, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729615.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VT98

Conserved Domains (2) summary

COG0724
Location:437 → 525

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12407
Location:443 → 518

RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
NM_001104102.4 → NP_001097572.1 RNA-binding Fox protein 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097572.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7YU08

Conserved Domains (2) summary

COG0724
Location:371 → 459

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12407
Location:377 → 452

RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
NM_001370003.1 → NP_001356980.1 RNA-binding Fox protein 1, isoform N [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4D6K632

Conserved Domains (2) summary

TIGR01628
Location:373 → 596

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12407
Location:377 → 452

RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
NM_001104103.3 → NP_001097573.1 RNA-binding Fox protein 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097573.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JNQ5

Conserved Domains (2) summary

COG0724
Location:371 → 459

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12407
Location:377 → 452

RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
NM_001104104.3 → NP_001097574.2 RNA-binding Fox protein 1, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097574.2

Status: REVIEWED

UniProtKB/TrEMBL

A8JNQ4

Conserved Domains (2) summary

COG0724
Location:437 → 525

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12407
Location:443 → 518

RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A4D6K632		A0A4D6K632
A8JNQ4		A8JNQ4
A8JNQ5		A8JNQ5
M9ND74		M9ND74
M9NFQ7		M9NFQ7
M9PF74		M9PF74
Q7YU08		Q7YU08
Q8MSP1		Q8MSP1
Q8T3Z3		Q8T3Z3
Q9VT98		Q9VT98
Q9VT99		Q9VT99