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Blos2 Biogenesis of lysosome-related organelles complex 1, subunit 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39234, updated on 9-Dec-2024

Summary

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Official Symbol
Blos2provided by FlyBase
Official Full Name
Biogenesis of lysosome-related organelles complex 1, subunit 2provided by FlyBase
Primary source
FLYBASE:FBgn0036118
Locus tag
Dmel_CG14145
See related
AllianceGenome:FB:FBgn0036118
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
blos2; BLOS2; CG14145; DmBlos2; Dmel\CG14145; NP_648427
Summary
Enables protein homodimerization activity. Involved in autophagosome-lysosome fusion. Predicted to be part of BLOC-1 complex; BORC complex; and gamma-tubulin complex. Orthologous to human BLOC1S2 (biogenesis of lysosomal organelles complex 1 subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Blos2 in Genome Data Viewer
Location:
68A3-68A3; 3-34 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11061571..11062215)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11054671..11055315)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45119 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Suppressor of Under-Replication

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity. Mullin AP, et al. J Neurosci, 2015 Jan 7. PMID 25568125, Free PMC Article
  2. Decoding the nexus: branched-chain amino acids and their connection with sleep, circadian rhythms, and cardiometabolic health. Li H, et al. Neural Regen Res, 2025 May 1. PMID 39075896, Free PMC Article
  3. A data-mining approach to rank candidate protein-binding partners-The case of biogenesis of lysosome-related organelles complex-1 (BLOC-1). Rodriguez-Fernandez IA, et al. J Inherit Metab Dis, 2009 Apr. PMID 19083121, Free PMC Article
  4. Pallidin function in Drosophila surface glia regulates sleep and is dependent on amino acid availability. Li H, et al. Cell Rep, 2023 Sep 26. PMID 37682712
  5. Drosophila Arl8 is a general positive regulator of lysosomal fusion events. Boda A, et al. Biochim Biophys Acta Mol Cell Res, 2019 Apr. PMID 30590083

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome-lysosome fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysosome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of BLOC-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BLOC-1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of BORC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
biogenesis of lysosome-related organelles complex 1, subunit 2
Names
BLOC-1 subunit 2
Blos2-PA
CG14145-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11061571..11062215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140170.2 → NP_648427.1  biogenesis of lysosome-related organelles complex 1, subunit 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648427.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTE0
    UniProtKB/TrEMBL
    A0A1B2AKW7
    Related
    FBpp0075932
    Conserved Domains (1) summary
    pfam10046
    Location:51 → 145
    BLOC1_2; Biogenesis of lysosome-related organelles complex-1 subunit 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTE0.2 Q9VTE0

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