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Mocs1 Molybdenum cofactor synthesis 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39238, updated on 4-Jan-2025

Summary

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Official Symbol
Mocs1provided by FlyBase
Official Full Name
Molybdenum cofactor synthesis 1provided by FlyBase
Primary source
FLYBASE:FBgn0263241
Locus tag
Dmel_CG33048
See related
AllianceGenome:FB:FBgn0263241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33048; CG7858; Dmel\CG33048; lxd; Mocs1A; MOCS1A; Mocs1A-B; Mocs1B; MOCS1B; mocsI; MocsI; MOCSI; Mosc1A+Mosc1B; pfs
Summary
Predicted to enable GTP 3',8'-cyclase activity and cyclic pyranopterin monophosphate synthase activity. Involved in inter-male aggressive behavior. Predicted to be active in mitochondrial matrix. Is expressed in several structures, including adult brain; embryonic/larval mushroom body; ganglia; imaginal disc; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type A. Orthologous to human MOCS1 (molybdenum cofactor synthesis 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Mocs1 in Genome Data Viewer
Location:
68A4-68A4; 3-34 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11070526..11073348)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11063626..11066448)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Suppressor of Under-Replication Neighboring gene uncharacterized protein Neighboring gene Prefoldin 2 Neighboring gene Nucleolar complex protein 1 Neighboring gene JIL-1 kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nutritional control of xanthine dehydrogenase. II. Effects on xanthine dehydrogenase and aldehyde oxidase of culturing wild-type and mutant Drosophila on different levels of molybdenum. Duke EJ, et al. Biochem Genet, 1975 Feb. PMID 806286
  2. Effect of adenine metabolites on survival of Drosophila melanogaster of low xanthine dehydrogenase activity. Ho YK, et al. Comp Biochem Physiol B, 1992 Oct. PMID 1424569
  3. Nucleotide variations in the lxd region of Drosophila melanogaster: characterization of a candidate modifier of lifespan. Tahoe NM, et al. Gene, 2002 Sep 4. PMID 12384303
  4. The peacefulness gene promotes aggression in Drosophila. Ramin M, et al. Mol Brain, 2019 Jan 3. PMID 30606245, Free PMC Article
  5. Genetical toxicogenomics in Drosophila identifies master-modulatory loci that are regulated by developmental exposure to lead. Ruden DM, et al. Neurotoxicology, 2009 Nov. PMID 19737576, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP 3',8'-cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP 3',8'-cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclic pyranopterin monophosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclic pyranopterin monophosphate synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in Mo-molybdopterin cofactor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inter-male aggressive behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in iron-sulfur cluster assembly TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
molybdenum cofactor synthesis 1
Names
CG33048-PA
CG33048-PC
Mocs1-PA
Mocs1-PC
low xanthine dehydrogenase
molybdenum cofactor synthesis 1 ortholog
peacefulness
NP_788494.1
NP_788495.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11070526..11073348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176316.2 → NP_788494.1  molybdenum cofactor synthesis 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788494.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IQF1, Q9NIG3, Q9NIG4, Q9VTE4
    Related
    FBpp0075935
    Conserved Domains (4) summary
    cd01335
    Location:74 → 249
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    PRK00164
    Location:59 → 366
    moaA; molybdenum cofactor biosynthesis protein A; Reviewed
    PRK09364
    Location:399 → 555
    moaC; molybdenum cofactor biosynthesis protein MoaC; Provisional
    pfam06463
    Location:240 → 367
    Mob_synth_C; Molybdenum Cofactor Synthesis C

  2. NM_176317.2 → NP_788495.1  molybdenum cofactor synthesis 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788495.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IQF1
    Related
    FBpp0075934
    Conserved Domains (3) summary
    cd01335
    Location:74 → 249
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    PLN02951
    Location:43 → 385
    PLN02951; Molybderin biosynthesis protein CNX2
    pfam06463
    Location:240 → 367
    Mob_synth_C; Molybdenum Cofactor Synthesis C
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8I688 Q8I688
Q8IQF1.1 Q8IQF1
Q9NIG2 Q9NIG2

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