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Iyd Iodotyrosine deiodinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39242, updated on 4-Jan-2025

Summary

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Official Symbol
Iydprovided by FlyBase
Official Full Name
Iodotyrosine deiodinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0286980
Locus tag
Dmel_CG46438
See related
AllianceGenome:FB:FBgn0286980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cdt; CG46438; CG6279; CG6279-PB; Dmel\CG46438; dmIYD; IYD
Old locus tag
Dmel_CG6279
Summary
Enables FMN binding activity and iodotyrosine deiodinase activity. Involved in positive regulation of fertilization. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Iyd in Genome Data Viewer
Location:
68A6-68A6; 3-34 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11093371..11096245, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11086471..11089345, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Nucleolar complex protein 1 Neighboring gene JIL-1 kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Inverted repeat binding protein 18 kDa Neighboring gene beta-Amyloid precursor protein binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The importance of a halotyrosine dehalogenase for Drosophila fertility. Phatarphekar A, et al. J Biol Chem, 2018 Jun 29. PMID 29764939, Free PMC Article
  2. Misregulation of bromotyrosine compromises fertility in male Drosophila. Su Q, et al. Proc Natl Acad Sci U S A, 2024 May 21. PMID 38748578, Free PMC Article
  3. Functional analysis of iodotyrosine deiodinase from drosophila melanogaster. Phatarphekar A, et al. Protein Sci, 2016 Dec. PMID 27643701, Free PMC Article
  4. Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages. Zhang W, et al. Genetics, 2003 Nov. PMID 14668387, Free PMC Article
  5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iodotyrosine deiodinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tyrosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
iodotyrosine deiodinase
Names
CG46438-PB
CG46438-PC
Iyd-PB
Iyd-PC
condet
NP_001163414.1
NP_001369045.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11093371..11096245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382155.1 → NP_001369045.1  iodotyrosine deiodinase, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JIB2
    UniProtKB/TrEMBL
    Q8T3Q0
    Conserved Domains (1) summary
    cd02144
    Location:89 → 283
    iodotyrosine_dehalogenase; iodotyrosine dehalogenase

  2. NM_001169943.1 → NP_001163414.1  iodotyrosine deiodinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163414.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JIB2
    UniProtKB/TrEMBL
    Q8T3Q0
    Conserved Domains (1) summary
    cd02144
    Location:89 → 283
    iodotyrosine_dehalogenase; iodotyrosine dehalogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JIB2.1 E1JIB2

Gene LinkOut

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