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FoxK Forkhead box K [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39252, updated on 4-Jan-2025

Summary

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Official Symbol
FoxKprovided by FlyBase
Official Full Name
Forkhead box Kprovided by FlyBase
Primary source
FLYBASE:FBgn0036134
Locus tag
Dmel_CG11799
See related
AllianceGenome:FB:FBgn0036134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11799; dFoxK; Dmel\CG11799; DmLD16137; DmMNF; fd68A; fork head transcription factor long isoform; fork head transcription factor short isoform; Mnf; MNF
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of gene expression; response to virus; and visceral mesoderm-endoderm interaction involved in midgut development. Is expressed in several structures, including anterior-posterior subdivision of organism; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Orthologous to several human genes including FOXK2 (forkhead box K2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See FoxK in Genome Data Viewer
Location:
68A7-68A7; 3-34 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11114169..11120783, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11107269..11113883, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene emei Neighboring gene Superoxide dismutase 1 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene Ubiquitin fusion-degradation 1-like Neighboring gene Na[+]-dependent inorganic phosphate cotransporter type III Neighboring gene no optic lobe

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evaluation of potential reference genes for reverse transcription-qPCR studies of physiological responses in Drosophila melanogaster. Ponton F, et al. J Insect Physiol, 2011 Jun. PMID 21435341
  2. FoxK mediates TGF-beta signalling during midgut differentiation in flies. Casas-Tinto S, et al. J Cell Biol, 2008 Dec 15. PMID 19075113, Free PMC Article
  3. The transcription factor FoxK participates with Nup98 to regulate antiviral gene expression. Panda D, et al. mBio, 2015 Apr 7. PMID 25852164, Free PMC Article
  4. Survey of forkhead domain encoding genes in the Drosophila genome: Classification and embryonic expression patterns. Lee HH, et al. Dev Dyn, 2004 Feb. PMID 14745961
  5. Phylogenetic relationships of the Fox (Forkhead) gene family in the Bilateria. Mazet F, et al. Gene, 2003 Oct 16. PMID 14563554

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in midgut development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visceral mesoderm-endoderm interaction involved in midgut development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
forkhead box K
Names
CG11799-PG
CG11799-PH
CG11799-PI
CG11799-PJ
CG11799-PK
CG11799-PN
CG11799-PO
CG11799-PP
FoxK-PG
FoxK-PH
FoxK-PI
FoxK-PJ
FoxK-PK
FoxK-PN
FoxK-PO
FoxK-PP
Mnf
fork head box K
forkhead domain 68A
myocyte nuclear factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11114169..11120783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274773.2 → NP_001261702.1  forkhead box K, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261702.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PI07
    Conserved Domains (2) summary
    cd00060
    Location:170 → 253
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:452 → 539
    Forkhead; Forkhead domain

  2. NM_001274772.2 → NP_001261701.1  forkhead box K, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261701.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF47
    Conserved Domains (2) summary
    cd00060
    Location:170 → 253
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:453 → 540
    Forkhead; Forkhead domain

  3. NM_168443.3 → NP_729672.1  forkhead box K, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729672.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8F8
    Related
    FBpp0291179
    Conserved Domains (2) summary
    cd00060
    Location:170 → 253
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:447 → 534
    Forkhead; Forkhead domain

  4. NM_168446.2 → NP_729675.2  forkhead box K, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729675.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4QQA9, Q8IQE9
    Conserved Domains (2) summary
    cd00060
    Location:170 → 253
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:453 → 540
    Forkhead; Forkhead domain

  5. NM_168444.2 → NP_729673.2  forkhead box K, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729673.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4QQA9, Q8IQE9
    Conserved Domains (2) summary
    cd00060
    Location:170 → 253
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:453 → 540
    Forkhead; Forkhead domain

  6. NM_001274774.2 → NP_001261703.1  forkhead box K, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261703.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PC64
    Conserved Domains (2) summary
    cd00060
    Location:170 → 253
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:453 → 540
    Forkhead; Forkhead domain

  7. NM_140183.3 → NP_648440.2  forkhead box K, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648440.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4QQA9, Q8IQE9
    Conserved Domains (2) summary
    cd00060
    Location:170 → 253
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:453 → 540
    Forkhead; Forkhead domain

  8. NM_168445.3 → NP_729674.2  forkhead box K, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729674.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4QQA9, Q8IQE9
    Conserved Domains (2) summary
    cd00060
    Location:170 → 253
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:453 → 540
    Forkhead; Forkhead domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JL24 A0JL24
M9PC64 M9PC64
M9PF47 M9PF47
M9PI07 M9PI07
Q0E8F8 Q0E8F8
Q8IQE9 Q8IQE9
Q95RQ3 Q95RQ3
Q95RS1 Q95RS1

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