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GlcAT-P Glucuronyltransferase P [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39262, updated on 4-Jan-2025

Summary

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Official Symbol
GlcAT-Pprovided by FlyBase
Official Full Name
Glucuronyltransferase Pprovided by FlyBase
Primary source
FLYBASE:FBgn0036144
Locus tag
Dmel_CG6207
See related
AllianceGenome:FB:FBgn0036144
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6207; dGlcAT-BSII; dGlcAT-P; DGlcAT-P; Dmel\CG6207; DmGlcAT-BSII
Summary
Enables glucuronosyltransferase activity. Involved in protein N-linked glycosylation and protein O-linked glycosylation. Located in Golgi apparatus. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic head epidermis; epithelium; gland; and larval glial cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See GlcAT-P in Genome Data Viewer
Location:
68B1-68B1; 3-35 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11176954..11197536, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11170054..11190636, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene aarF domain containing kinase 5 Neighboring gene uncharacterized protein Neighboring gene procollagen lysyl hydroxylase Neighboring gene uncharacterized protein Neighboring gene noktochor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of three Drosophila melanogaster glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans. Two novel homologs exhibit broad specificity toward oligosaccharides from proteoglycans, glycoproteins, and glycosphingolipids. Kim BT, et al. J Biol Chem, 2003 Mar 14. PMID 12511570
  2. Glucuronylated core 1 glycans are required for precise localization of neuromuscular junctions and normal formation of basement membranes on Drosophila muscles. Itoh K, et al. Dev Biol, 2018 Apr 15. PMID 29499182, Free PMC Article
  3. Mucin-Type O-Glycosylation in the Drosophila Nervous System. Itoh K, et al. Front Neuroanat, 2021. PMID 34733141, Free PMC Article
  4. A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion. Valoskova K, et al. Elife, 2019 Mar 26. PMID 30910009, Free PMC Article
  5. Sprinter: a novel transmembrane protein required for Wg secretion and signaling. Goodman RM, et al. Development, 2006 Dec. PMID 17108000

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study confirms results showing that GlcAT-S and GlcAT-P can transfer GlcA to the O-linked T-antigen as well as to N-linked LacNAc-chains in vitro.
    Title: Functional Analysis of the Glucuronyltransferases GlcAT-P and GlcAT-S of Drosophila melanogaster: Distinct Activities towards the O-linked T-antigen.
  2. novel glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans
    Title: Identification and characterization of three Drosophila melanogaster glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans. Two novel homologs exhibit broad specificity toward oligosaccharides from proteoglycans, glycoproteins, and glycosphingolipids.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N-acetyllactosamine beta-1,3-glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables asioloorosomucoid beta-1,3-glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoprotein biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in glycosphingolipid biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteoglycan biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucuronyltransferase P
Names
CG6207-PA
CG6207-PB
CG6207-PC
CG6207-PD
CG6207-PE
GlcAT-P-PA
GlcAT-P-PB
GlcAT-P-PC
GlcAT-P-PD
GlcAT-P-PE
beta1,3-glucuronyltransferase-P
NP_001014581.1
NP_001246713.1
NP_001246714.1
NP_648448.1
NP_729685.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11176954..11197536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259785.2 → NP_001246714.1  glucuronyltransferase P, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246714.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V1U5
    Conserved Domains (1) summary
    cd00218
    Location:68 → 289
    GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

  2. NM_001259784.2 → NP_001246713.1  glucuronyltransferase P, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246713.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5BI43, Q8MSC2, Q95RU4, Q9VTG7
    UniProtKB/TrEMBL
    A2RVE7, M9NE76
    Conserved Domains (1) summary
    cd00218
    Location:231 → 452
    GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

  3. NM_001014581.3 → NP_001014581.1  glucuronyltransferase P, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014581.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V1U5
    Conserved Domains (1) summary
    cd00218
    Location:68 → 289
    GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

  4. NM_140191.3 → NP_648448.1  glucuronyltransferase P, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648448.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5BI43, Q8MSC2, Q95RU4, Q9VTG7
    UniProtKB/TrEMBL
    A2RVE7, M9NE76
    Related
    FBpp0075919
    Conserved Domains (1) summary
    cd00218
    Location:231 → 452
    GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

  5. NM_168451.4 → NP_729685.2  glucuronyltransferase P, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729685.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V1U5
    Conserved Domains (1) summary
    cd00218
    Location:68 → 289
    GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V1U5 A4V1U5
M9NE76 M9NE76
Q9VTG7.1 Q9VTG7

Gene LinkOut

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