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CG6168 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39273, updated on 4-Jan-2025

Summary

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Official Symbol
CG6168provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036154
Locus tag
Dmel_CG6168
See related
AllianceGenome:FB:FBgn0036154
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6168
Summary
Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. Is expressed in adult head. Orthologous to human QPCT (glutaminyl-peptide cyclotransferase) and QPCTL (glutaminyl-peptide cyclotransferase like). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG6168 in Genome Data Viewer
Location:
68C2-68C2; 3-36 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11319642..11321719, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11312742..11314819, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44361 Neighboring gene long non-coding RNA:CR46240 Neighboring gene long non-coding RNA:CR44721 Neighboring gene long non-coding RNA:CR44722 Neighboring gene long non-coding RNA:CR44723

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization. Schilling S, et al. Biochemistry, 2007 Sep 25. PMID 17722885
  2. Associations between sperm competition and natural variation in male reproductive genes on the third chromosome of Drosophila melanogaster. Fiumera AC, et al. Genetics, 2007 Jun. PMID 17435238, Free PMC Article
  3. Predicted seminal astacin-like protease is required for processing of reproductive proteins in Drosophila melanogaster. Ravi Ram K, et al. Proc Natl Acad Sci U S A, 2006 Dec 5. PMID 17116868, Free PMC Article
  4. Seminal fluid gene expression and reproductive fitness in Drosophila melanogaster. Patlar B, et al. BMC Ecol Evol, 2022 Feb 23. PMID 35196983, Free PMC Article
  5. Oh, the places they'll go: Female sperm storage and sperm precedence in Drosophila melanogaster. Schnakenberg SL, et al. Spermatogenesis, 2012 Jul 1. PMID 23087839, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutaminyl-peptide cyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminyl-peptide cyclotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sexual reproduction HEP PubMed 
Component Evidence Code Pubs
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG6168-PB
CG6168-PC
NP_001287032.1
NP_648459.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11319642..11321719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300103.1 → NP_001287032.1  uncharacterized protein Dmel_CG6168, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287032.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8E739, Q9VTH7
    Conserved Domains (1) summary
    cd03880
    Location:49 → 330
    M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

  2. NM_140202.2 → NP_648459.1  uncharacterized protein Dmel_CG6168, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648459.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8E739, Q9VTH7
    Related
    FBpp0075912
    Conserved Domains (1) summary
    cd03880
    Location:49 → 330
    M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTH7 Q9VTH7

Gene LinkOut

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