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CG7551 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39280, updated on 9-Dec-2024

Summary

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Official Symbol
CG7551provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036161
Locus tag
Dmel_CG7551
See related
AllianceGenome:FB:FBgn0036161
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT07524; Dmel\CG7551
Summary
Predicted to enable ketohexokinase activity. Predicted to be involved in several processes, including carbohydrate phosphorylation; response to hexose; and response to insulin. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (ketohexokinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG7551 in Genome Data Viewer
Location:
68C9-68C9; 3-36 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11458490..11459625)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11451590..11452725)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fumarase 3 Neighboring gene Vacuolar H[+] ATPase 16kD subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. Doggett K, et al. Dev Biol, 2011 Jul 15. PMID 21570388, Free PMC Article
  2. The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster. Zhou S, et al. Environ Health Perspect, 2016 Jul. PMID 26859824, Free PMC Article
  3. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
  4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
  5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ketohexokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ketohexokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ketohexokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carbohydrate phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fructose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of glycogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to fructose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to glucose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to insulin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to sucrose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG7551-PB
NP_648466.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11458490..11459625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140209.1 → NP_648466.1  uncharacterized protein Dmel_CG7551 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648466.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T4I0, Q9VTI4
    Related
    FBpp0075906, FBtr0076176
    Conserved Domains (1) summary
    cd01939
    Location:16 → 311
    Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T4I0 Q8T4I0

Gene LinkOut

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