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Akr1B - Aldo-keto reductase 1B

Enables aldose reductase (NADPH) activity. Involved in fructose biosynthetic process and sorbitol biosynthetic process. Located in extracellular space. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; follicle cell; and germline cell. Human ortholog(s) of this gene implicated in several diseases, including arteriosclerosis; congenital bile acid synthesis defect 2; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Dec 2024]

Genes similar to Akr1B

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Species Gene Architecture aa