U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG11658 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39319, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
CG11658provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036196
Locus tag
Dmel_CG11658
See related
AllianceGenome:FB:FBgn0036196
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.413; dFBXO25; Dmel\CG11658; FBXO12; Fbxo25
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including dorsal pharyngeal muscle primordium; larval muscle cell; larval muscle system; somatic muscle primordium; and trunk mesoderm. Used to study attention deficit hyperactivity disorder. Orthologous to human FBXO25 (F-box protein 25) and FBXO32 (F-box protein 32). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG11658 in Genome Data Viewer
Location:
68D2-68D2; 3-36 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11699496..11708553, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11692596..11701653, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Diphthamide biosynthesis 1 Neighboring gene dynein, axonemal, intermediate chain 2 Neighboring gene Coiled-coil domain containing 56 Neighboring gene Mitochondrial Transcription Factor B1 Neighboring gene crimpled Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes. Harich B, et al. J Child Psychol Psychiatry, 2020 May. PMID 31849056, Free PMC Article
  2. The RU486-dependent activation of the GeneSwitch system in adult muscles leads to severe adverse effects in Drosophila. Zappia MP, et al. G3 (Bethesda), 2024 May 7. PMID 38409337, Free PMC Article
  3. DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm. Mendoza-Garcia P, et al. Development, 2021 Dec 1. PMID 34905617, Free PMC Article
  4. Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP. Vandehoef C, et al. Cell Rep, 2020 Jun 9. PMID 32521261, Free PMC Article
  5. Drosophila as a Model for Tumor-Induced Organ Wasting. Saavedra P, et al. Adv Exp Med Biol, 2019. PMID 31520356

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
Inferred from Sequence Model
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISM
Inferred from Sequence Model
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG11658-PA
CG11658-PB
CG11658-PC
CG11658-PD
CG11658-PE

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11699496..11708553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206338.2 → NP_996060.1  uncharacterized protein Dmel_CG11658, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996060.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTM4

  2. NM_140241.3 → NP_648498.1  uncharacterized protein Dmel_CG11658, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648498.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTM4
    Related
    FBpp0075855

  3. NM_206336.2 → NP_996058.1  uncharacterized protein Dmel_CG11658, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996058.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTM4

  4. NM_206337.2 → NP_996059.1  uncharacterized protein Dmel_CG11658, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996059.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTM4

  5. NM_206339.2 → NP_996061.1  uncharacterized protein Dmel_CG11658, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996061.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTM4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTM4 Q9VTM4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous