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slc46a1 solute carrier family 46 member 1 [ Danio rerio (zebrafish) ]

Gene ID: 393255, updated on 2-Nov-2024

Summary

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Official Symbol
slc46a1provided by ZNC
Official Full Name
solute carrier family 46 member 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1012
See related
Ensembl:ENSDARG00000026149 AllianceGenome:ZFIN:ZDB-GENE-040426-1012
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56400
Summary
Predicted to enable methotrexate transmembrane transporter activity and symporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in endosome. Predicted to be active in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See slc46a1 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (28175658..28186529)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (28242782..28253653)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene unc-119 lipid binding chaperone a1 Neighboring gene forkhead box N1 Neighboring gene sterile alpha and TIR motif containing 1 Neighboring gene vitronectin a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish. Liang F, et al. Nat Commun, 2022 Jun 14. PMID 35701400, Free PMC Article
  2. Evolution of the tbx6/16 subfamily genes in vertebrates: insights from zebrafish. Ahn D, et al. Mol Biol Evol, 2012 Dec. PMID 22915831
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC56400

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables folic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables methotrexate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
proton-coupled folate transporter
Names
PCFT/HCP1
heme carrier protein 1
solute carrier family 46 (folate transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200285.1 → NP_956579.1  proton-coupled folate transporter

    See identical proteins and their annotated locations for NP_956579.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049421
    UniProtKB/Swiss-Prot
    Q7ZWG6
    Related
    ENSDARP00000032054.5, ENSDART00000037119.6
    Conserved Domains (2) summary
    cd06174
    Location:93 → 460
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:114 → 427
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    28175658..28186529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZWG6.1 GenPept UniProtKB/Swiss-Prot:Q7ZWG6

Gene LinkOut

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