CycA Cyclin A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CycAprovided by FlyBase
Official Full Name: Cyclin Aprovided by FlyBase
Primary source: FLYBASE:FBgn0000404
Locus tag: Dmel_CG5940
See related: AllianceGenome:FB:FBgn0000404
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0033/02; 0040/24; 0046/23; 0104/07; 0245/34; 0521/06; 0545/13; 1329/16; 1449/05; anon-WO0140519.128; CG5940; CLD3; Cyc A; cycA; CYCA; cyclin A; CYCLIN A; CyclinA; dCycA; DmcycA; Dmel\CG5940; hari; l(3)03946; l(3)183; l(3)68Ea; l(3)j3C8; l(3)neo114; l(3)rsg11; rsg11; S(rux)3B
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including asymmetric neuroblast division; regulation of mitotic cell cycle; and syncytial blastoderm mitotic cell cycle. Located in several cellular components, including fusome; male germ cell nucleus; and spectrosome. Is expressed in several structures, including brain; germline cell; head epidermis primordium; presumptive embryonic/larval system; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including CCNA2 (cyclin A2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 68E1-68E1; 3-37 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11826719..11833578, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11819819..11826678, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MARF1 binds cyclin A mRNA and shortens its poly-A tail to reduce Cyclin A protein level during oocyte maturation.
Title: LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes.
dIAP1 and Cyclin A have been identified as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population in Drosophila wing morphogenesis.
Title: JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling.
TARA regulates CycA protein levels and genetically and physically interacts with CycA to promote sleep.
Title: TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila.
mitotic ER reorganization events rely on CycA and that control and timing of nuclear and cytoplasmic events during mitosis
Title: Spatial reorganization of the endoplasmic reticulum during mitosis relies on mitotic kinase cyclin A in the early Drosophila embryo.
Through visualization of double heterozygous embryos, we determines that spir cooperates with CycA for heart cell specification and division.
Title: Spire, an actin nucleation factor, regulates cell division during Drosophila heart development.
findings show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep
Title: Control of sleep by cyclin A and its regulator.
It was shown that CycA accumulate during the last period of endoreplication, both CycA loss and gain of function induce changes in endoreplication dynamics and reduce the number of endocycles, and heterochromatin localisation of ORC2 depends on CycA.
Title: CycA is involved in the control of endoreplication dynamics in the Drosophila bristle lineage.
Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cells.
Title: Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cells.
Effete/APC-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells
Title: Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila.
Drosophila cyclin A destruction during mitosis requires both N- and C-terminal residues, emphasizing synergistic action by different parts of the protein that facilitate recognition and degradation.
Title: Cyclin A degradation employs preferentially used lysines and a cyclin box function other than Cdk1 binding.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1876 (e-PCR)
- UniSTS:72852

Dm0585 (e-PCR)
- UniSTS:26590

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle, embryonic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic nuclear division	IEP Inferred from Expression Pattern more info	PubMed
involved_in syncytial blastoderm mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin A2-CDK2 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spectrosome	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclin A

Names: CG5940-PA; CG5940-PC; CycA-PA; CycA-PC; cyclin-A; cyclinA; rose-gespleten region interval 11; suppressor of rux 3B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

11826719..11833578 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259795.2 → NP_001246724.1 cyclin A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246724.1

Status: REVIEWED

UniProtKB/TrEMBL

F3YDK3, M9NFR3

Conserved Domains (2) summary

pfam00134
Location:205 → 331

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:333 → 449

Cyclin_C; Cyclin, C-terminal domain
NM_079306.4 → NP_524030.2 cyclin A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524030.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P14785, Q8IGR7, Q9VTP6, Q9VTP7

UniProtKB/TrEMBL

F3YDK3

Related

FBpp0075807

Conserved Domains (2) summary

pfam00134
Location:206 → 332

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:334 → 450

Cyclin_C; Cyclin, C-terminal domain