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byn brachyenteron [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39349, updated on 4-Jan-2025

Summary

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Official Symbol
bynprovided by FlyBase
Official Full Name
brachyenteronprovided by FlyBase
Primary source
FLYBASE:FBgn0011723
Locus tag
Dmel_CG7260
See related
AllianceGenome:FB:FBgn0011723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
apro; Bra; Byn; byn/apro; CG7260; D-TRA; D-Trg; Dm-BYN; dm-Trg; Dmel\CG7260; DTrg; Tra; trg; Trg
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and protein homodimerization activity. Involved in Malpighian tubule morphogenesis; midgut development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including amnioproctodeal invagination; embryonic small intestine; gut section; hindgut anlage; and hindgut anlage in statu nascendi. Human ortholog(s) of this gene implicated in adrenocorticotropic hormone deficiency; alcohol dependence; inherited metabolic disorder; and neural tube defect. Orthologous to several human genes including TBX19 (T-box transcription factor 19). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See byn in Genome Data Viewer
Location:
68E3-68E3; 3-37 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11927693..11935919)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11920793..11929019)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Succinate dehydrogenase, subunit A (flavoprotein)-like Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 4-related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of Brachyury proteins: identification of a novel regulatory domain conserved within Bilateria. Marcellini S, et al. Dev Biol, 2003 Aug 15. PMID 12921737
  2. Novel tissue units of regional differentiation in the gut epithelium of Drosopbila, as revealed by P-element-mediated detection of enhancer. Murakami R, et al. Rouxs Arch Dev Biol, 1994 Mar. PMID 28305621
  3. When Brachyury meets Smad1: the evolution of bilateral symmetry during gastrulation. Marcellini S. Bioessays, 2006 Apr. PMID 16547957
  4. Optomotor-blind in the development of the Drosophila HS and VS lobula plate tangential cells. Sen A, et al. J Neurogenet, 2014 Sep-Dec. PMID 24912380
  5. The homeodomain transcription factor Orthopedia is involved in development of the Drosophila hindgut. Hildebrandt K, et al. Hereditas, 2020 Nov 19. PMID 33213520, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brachyenteron activates the homeobox gene orthopedia in a dose-dependent manner via multiple consensus binding sites.
    Title: Brachyury proteins regulate target genes through modular binding sites in a cooperative fashion.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate determination TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in germ cell migration TAS
Traceable Author Statement
more info
 PubMed 
involved_in heart morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hindgut morphogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in hindgut morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hindgut morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in mesoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mesoderm migration involved in gastrulation TAS
Traceable Author Statement
more info
 PubMed 
involved_in midgut development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
brachyenteron
Names
CG7260-PB
CG7260-PC
T related antigen
T-related gene
aproctous
brachyury
byn-PB
byn-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11927693..11935919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274801.1 → NP_001261730.1  brachyenteron, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261730.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEX3
    Conserved Domains (1) summary
    cd00182
    Location:86 → 268
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

  2. NM_079307.2 → NP_524031.2  brachyenteron, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524031.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P55965, Q9VTQ7
    Conserved Domains (1) summary
    cd00182
    Location:86 → 268
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEX3 M9PEX3
P55965.2 P55965

Gene LinkOut

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