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rols rolling pebbles [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39368, updated on 4-Jan-2025

Summary

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Official Symbol
rolsprovided by FlyBase
Official Full Name
rolling pebblesprovided by FlyBase
Primary source
FLYBASE:FBgn0041096
Locus tag
Dmel_CG32096
See related
AllianceGenome:FB:FBgn0041096
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0257455.19; ants; Ants; ANTS; ants/rols; CG12277; CG17155; CG32096; CG5679; Dmel\CG32096; l(3)08232; l(3)68Fd; l(3)j2A6; Rol/Ants; Rols; Rols6; rols7; Rols7; rols\ants
Summary
Enables cell adhesion molecule binding activity. A structural constituent of muscle. Involved in anterior Malpighian tubule development; border follicle cell migration; and striated muscle cell differentiation. Located in Z disc and apical plasma membrane. Colocalizes with cell-cell junction. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; gut section; muscle cell; and myoblast. Used to study intellectual developmental disorder with autistic features and language delay, with or without seizures. Human ortholog(s) of this gene implicated in intellectual developmental disorder with autistic features and language delay, with or without seizures. Orthologous to human TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1) and TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See rols in Genome Data Viewer
Location:
68F1-68F1; 3-38 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12008225..12064859, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12001325..12057959, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Pop2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43994 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Semaphorin 5c Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders. Guo H, et al. Nat Commun, 2019 Oct 15. PMID 31616000, Free PMC Article
  2. Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma. Avirneni-Vadlamudi U, et al. J Clin Invest, 2012 Jan. PMID 22182840, Free PMC Article
  3. Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks. Cannavò E, et al. Curr Biol, 2016 Jan 11. PMID 26687625, Free PMC Article
  4. Drosophila rolling pebbles: a multidomain protein required for myoblast fusion that recruits D-Titin in response to the myoblast attractant Dumbfounded. Menon SD, et al. Dev Cell, 2001 Nov. PMID 11709189
  5. Myoblasts fuse when loner meets ARF6. Donaldson JG. Dev Cell, 2003 Oct. PMID 14536050

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. rols is expressed in glial cells, and its disruption affects behavioral outcomes.
    Title: Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders.
  2. Mhcl interacts with rolling pebbles 7 during myogenesis.
    Title: Myosin heavy chain-like localizes at cell contact sites during Drosophila myoblast fusion and interacts in vitro with Rolling pebbles 7.
  3. Results suggest an additive function of the intracellular domain of Duf and an early function of Rols and Loner which is independent of Duf.
    Title: The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner.
  4. Genetic interaction of rols6, myoblast city protein, and rac GTP-binding proteins might lead to proper Malpighian tubule morphology.
    Title: In Drosophila melanogaster, the rolling pebbles isoform 6 (Rols6) is essential for proper Malpighian tubule morphology.
  5. This implicates the Duf-Rols7 positive feedback loop to the occurrence of fusion at specific sites along the membrane and provides a mechanism by which the rate of fusion is controlled.
    Title: A positive feedback loop between Dumbfounded and Rolling pebbles leads to myotube enlargement in Drosophila.
  6. In summary, these data show that besides the role in myoblast fusion, Rols7 is a scaffold protein during myofibrillogenesis and in the Z-line of the sarcomere as well as in the terminal Z-disc linking the muscle to the epidermal attachment sites.
    Title: Drosophila rolling pebbles colocalises and putatively interacts with alpha-Actinin and the Sls isoform Zormin in the Z-discs of the sarcomere and with Dumbfounded/Kirre, alpha-Actinin and Zormin in the terminal Z-discs.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of muscle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior Malpighian tubule development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sarcomere organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rolling pebbles
Names
CG32096-PA
CG32096-PB
CG32096-PC
CG32096-PD
CG32096-PE
CG32096-PF
CG32096-PG
CG32096-PH
CG32096-PI
antisocial
rolling pebbles 7
rols-PA
rols-PB
rols-PC
rols-PD
rols-PE
rols-PF
rols-PG
rols-PH
rols-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12008225..12064859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274810.1 → NP_001261739.1  rolling pebbles, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261739.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PC91, Q8WS24
    Conserved Domains (7) summary
    cd00204
    Location:1447 → 1573
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1634 → 1666
    TPR; TPR repeat [structural motif]
    pfam12796
    Location:1491 → 1583
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:1634 → 1710
    TPR_11; TPR repeat
    pfam13857
    Location:1261 → 1316
    Ank_5; Ankyrin repeats (many copies)
    pfam14634
    Location:327 → 364
    zf-RING_5; zinc-RING finger domain
    sd00045
    Location:1489 → 1517
    ANK; ANK repeat [structural motif]

  2. NM_001274808.1 → NP_001261737.1  rolling pebbles, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261737.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF75, Q8WS24
    Conserved Domains (7) summary
    cd00204
    Location:1448 → 1574
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1635 → 1667
    TPR; TPR repeat [structural motif]
    pfam12796
    Location:1492 → 1584
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:1635 → 1711
    TPR_11; TPR repeat
    pfam13857
    Location:1262 → 1317
    Ank_5; Ankyrin repeats (many copies)
    pfam14634
    Location:327 → 364
    zf-RING_5; zinc-RING finger domain
    sd00045
    Location:1490 → 1518
    ANK; ANK repeat [structural motif]

  3. NM_168487.2 → NP_729778.1  rolling pebbles, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729778.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WS24, Q9VTS9
    Related
    FBpp0075785
    Conserved Domains (7) summary
    cd00204
    Location:1549 → 1675
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1736 → 1768
    TPR; TPR repeat [structural motif]
    pfam12796
    Location:1593 → 1685
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:1736 → 1812
    TPR_11; TPR repeat
    pfam13857
    Location:1363 → 1418
    Ank_5; Ankyrin repeats (many copies)
    pfam14634
    Location:327 → 364
    zf-RING_5; zinc-RING finger domain
    sd00045
    Location:1591 → 1619
    ANK; ANK repeat [structural motif]

  4. NM_001274809.1 → NP_001261738.1  rolling pebbles, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261738.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PI28, Q8WTD1
    Conserved Domains (7) summary
    cd00204
    Location:1217 → 1343
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1404 → 1436
    TPR; TPR repeat [structural motif]
    pfam12796
    Location:1261 → 1353
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:1404 → 1480
    TPR_11; TPR repeat
    pfam13857
    Location:1031 → 1086
    Ank_5; Ankyrin repeats (many copies)
    pfam14634
    Location:97 → 134
    zf-RING_5; zinc-RING finger domain
    sd00045
    Location:1259 → 1287
    ANK; ANK repeat [structural motif]

  5. NM_168488.2 → NP_729779.1  rolling pebbles, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729779.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WTD1, Q95NR3, Q9VTS8
    Related
    FBpp0075788
    Conserved Domains (7) summary
    cd00204
    Location:1218 → 1344
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1405 → 1437
    TPR; TPR repeat [structural motif]
    pfam12796
    Location:1262 → 1354
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:1405 → 1481
    TPR_11; TPR repeat
    pfam13857
    Location:1032 → 1087
    Ank_5; Ankyrin repeats (many copies)
    pfam14634
    Location:97 → 134
    zf-RING_5; zinc-RING finger domain
    sd00045
    Location:1260 → 1288
    ANK; ANK repeat [structural motif]

  6. NM_168489.2 → NP_729780.1  rolling pebbles, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729780.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WS23, Q95V14, Q9VTS6
    Related
    FBpp0075789
    Conserved Domains (7) summary
    cd00204
    Location:1319 → 1445
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1506 → 1538
    TPR; TPR repeat [structural motif]
    pfam00097
    Location:97 → 134
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam12796
    Location:1363 → 1455
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:1506 → 1582
    TPR_11; TPR repeat
    pfam13857
    Location:1133 → 1188
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:1361 → 1389
    ANK; ANK repeat [structural motif]

  7. NM_001274807.1 → NP_001261736.1  rolling pebbles, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261736.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFC6, Q8WS23
    Conserved Domains (7) summary
    cd00204
    Location:1318 → 1444
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1505 → 1537
    TPR; TPR repeat [structural motif]
    pfam00097
    Location:97 → 134
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam12796
    Location:1362 → 1454
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:1505 → 1581
    TPR_11; TPR repeat
    pfam13857
    Location:1132 → 1187
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:1360 → 1388
    ANK; ANK repeat [structural motif]

  8. NM_168490.2 → NP_729781.1  rolling pebbles, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729781.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WS23, Q95V14, Q9VTS6
    Related
    FBpp0075787
    Conserved Domains (7) summary
    cd00204
    Location:1319 → 1445
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1506 → 1538
    TPR; TPR repeat [structural motif]
    pfam00097
    Location:97 → 134
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam12796
    Location:1363 → 1455
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:1506 → 1582
    TPR_11; TPR repeat
    pfam13857
    Location:1133 → 1188
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:1361 → 1389
    ANK; ANK repeat [structural motif]

  9. NM_140285.3 → NP_648542.1  rolling pebbles, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648542.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WTD1, Q95NR3, Q9VTS8
    Related
    FBpp0075786
    Conserved Domains (7) summary
    cd00204
    Location:1218 → 1344
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00006
    Location:1405 → 1437
    TPR; TPR repeat [structural motif]
    pfam12796
    Location:1262 → 1354
    Ank_2; Ankyrin repeats (3 copies)
    pfam13414
    Location:1405 → 1481
    TPR_11; TPR repeat
    pfam13857
    Location:1032 → 1087
    Ank_5; Ankyrin repeats (many copies)
    pfam14634
    Location:97 → 134
    zf-RING_5; zinc-RING finger domain
    sd00045
    Location:1260 → 1288
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PC91 M9PC91
M9PF75 M9PF75
M9PFC6 M9PFC6
M9PI28 M9PI28
Q8WS23 Q8WS23
Q8WS24 Q8WS24
Q8WTD1 Q8WTD1
Q8WTD2 Q8WTD2
Q9VTS6 Q9VTS6
Q9VTS8 Q9VTS8
Q9VTS9 Q9VTS9

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