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lypla2 lysophospholipase 2 [ Danio rerio (zebrafish) ]

Gene ID: 393722, updated on 4-Jan-2025

Summary

Official Symbol
lypla2provided by ZNC
Official Full Name
lysophospholipase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1715
See related
Ensembl:ENSDARG00000053656 AllianceGenome:ZFIN:ZDB-GENE-040426-1715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:73210
Summary
Predicted to enable carboxylic ester hydrolase activity and palmitoyl-(protein) hydrolase activity. Predicted to be involved in prostaglandin catabolic process. Predicted to be active in cytoplasm. Orthologous to human LYPLA2 (lysophospholipase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See lypla2 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (43884128..43902548)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (44288536..44306975)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108180087 Neighboring gene PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 Neighboring gene ankyrin repeat and IBR domain containing 1a Neighboring gene GATA zinc finger domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Clone Names

  • MGC73210, CU062425.1

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables palmitoyl-(protein) hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in prostaglandin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
acyl-protein thioesterase 2
Names
lysophospholipase II
NP_957043.1
XP_005159836.1
XP_021323691.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200749.2NP_957043.1  acyl-protein thioesterase 2

    See identical proteins and their annotated locations for NP_957043.1

    Status: VALIDATED

    Source sequence(s)
    CU062425, EH536698, EH557949
    UniProtKB/TrEMBL
    A0A8M1PHT4, Q6PBW8
    Related
    ENSDARP00000120420.2, ENSDART00000139684.4
    Conserved Domains (1) summary
    pfam02230
    Location:14227
    Abhydrolase_2; Phospholipase/Carboxylesterase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    43884128..43902548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468016.2XP_021323691.1  acyl-protein thioesterase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M1PHT4, Q6PBW8
    Conserved Domains (1) summary
    pfam02230
    Location:14227
    Abhydrolase_2; Phospholipase/Carboxylesterase
  2. XM_005159779.4XP_005159836.1  acyl-protein thioesterase 2 isoform X1

    See identical proteins and their annotated locations for XP_005159836.1

    UniProtKB/TrEMBL
    A0A8M1PHT4, Q6PBW8
    Related
    ENSDARP00000118541.1, ENSDART00000135599.3
    Conserved Domains (1) summary
    pfam02230
    Location:14227
    Abhydrolase_2; Phospholipase/Carboxylesterase