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fscn2b fascin actin-bundling protein 2b, retinal [ Danio rerio (zebrafish) ]

Gene ID: 393743, updated on 4-Jan-2025

Summary

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Official Symbol
fscn2bprovided by ZNC
Official Full Name
fascin actin-bundling protein 2b, retinalprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1740
See related
Ensembl:ENSDARG00000074396 AllianceGenome:ZFIN:ZDB-GENE-040426-1740
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fscn2; fscn1l; zgc:73272
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly; cell migration; and establishment or maintenance of cell polarity. Predicted to act upstream of or within actin filament organization. Predicted to be located in cytoskeleton. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in eye; hair cell anterior macula; otic vesicle; retina; and retinal photoreceptor layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 30. Orthologous to human FSCN2 (fascin actin-bundling protein 2, retinal). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See fscn2b in Genome Data Viewer
Location:
chromosome: 12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (34439254..34458662, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (34338191..34357599, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 235b Neighboring gene baculoviral IAP repeat containing 5a Neighboring gene uncharacterized LOC103911938 Neighboring gene uncharacterized LOC137496829

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The Stereociliary Paracrystal Is a Dynamic Cytoskeletal Scaffold In Vivo. Hwang P, et al. Cell Rep, 2015 Nov 17. PMID 26549442, Free PMC Article
  2. Retina-specific protein fascin 2 is an actin cross-linker associated with actin bundles in photoreceptor inner segments and calycal processes. Lin-Jones J, et al. Invest Ophthalmol Vis Sci, 2007 Mar. PMID 17325187
  3. Zebrafish Models for the Mechanosensory Hair Cell Dysfunction in Usher Syndrome 3 Reveal That Clarin-1 Is an Essential Hair Bundle Protein. Gopal SR, et al. J Neurosci, 2015 Jul 15. PMID 26180195, Free PMC Article
  4. Tmc Reliance Is Biased by the Hair Cell Subtype and Position Within the Ear. Zhu S, et al. Front Cell Dev Biol, 2020. PMID 33490059, Free PMC Article
  5. Fascin 2b is a component of stereocilia that lengthens actin-based protrusions. Chou SW, et al. PLoS One, 2011. PMID 21625653, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. fascin 2b plays a key role in shaping stereocilia
    Title: Fascin 2b is a component of stereocilia that lengthens actin-based protrusions.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC73272

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin filament organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fascin-2b
Names
fascin 2B
fascin homolog 1-like, actin-bundling protein
fascin homolog 2, actin-bundling protein, retinal b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200770.2 → NP_957064.2  fascin-2b

    See identical proteins and their annotated locations for NP_957064.2

    Status: PROVISIONAL

    Source sequence(s)
    EU580143
    UniProtKB/TrEMBL
    B2LT50
    Related
    ENSDARP00000098380.3, ENSDART00000111717.4
    Conserved Domains (2) summary
    cd00257
    Location:379 → 490
    Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
    pfam06268
    Location:19 → 131
    Fascin; Fascin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    34439254..34458662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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