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CG5645 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39382, updated on 4-Jan-2025

Summary

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Official Symbol
CG5645provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036254
Locus tag
Dmel_CG5645
See related
AllianceGenome:FB:FBgn0036254
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5645
Summary
Predicted to be involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of 90S preribosome. Predicted to be active in nucleolus. Is expressed in anterior midgut primordium; organism; posterior midgut primordium; salivary gland body primordium; and trunk mesoderm. Orthologous to human KRI1 (KRI1 homolog). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG5645 in Genome Data Viewer
Location:
68F5-68F5; 3-38 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12133771..12136706, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12126871..12129806, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR11538 Neighboring gene Larval serum protein 2 Neighboring gene antisense RNA:CR45892 Neighboring gene differentially expressed in FDCP 8 homolog Neighboring gene Autophagy-related 12 Neighboring gene NADH dehydrogenase (ubiquinone) SGDH subunit Neighboring gene Rho GTPase activating protein at 68F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling. Vinayagam A, et al. Cell Rep, 2016 Sep 13. PMID 27626673, Free PMC Article
  2. Protein interaction mapping: a Drosophila case study. Formstecher E, et al. Genome Res, 2005 Mar. PMID 15710747, Free PMC Article
  3. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article
  4. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article
  5. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5645-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12133771..12136706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140293.3 → NP_648550.1  uncharacterized protein Dmel_CG5645 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648550.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTU0
    Related
    FBpp0075756
    Conserved Domains (2) summary
    pfam05178
    Location:332 → 423
    Kri1; KRI1-like family
    pfam12936
    Location:499 → 587
    Kri1_C; KRI1-like family C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTU0.1 Q9VTU0

Gene LinkOut

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Chemical Information
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