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eIF3l eukaryotic translation initiation factor 3 subunit l [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39386, updated on 4-Jan-2025

Summary

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Official Symbol
eIF3lprovided by FlyBase
Official Full Name
eukaryotic translation initiation factor 3 subunit lprovided by FlyBase
Primary source
FLYBASE:FBgn0036258
Locus tag
Dmel_CG5642
See related
AllianceGenome:FB:FBgn0036258
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5642; Dmel\CG5642
Summary
Predicted to contribute to translation initiation factor activity. Predicted to be involved in translational initiation. Located in cytosol. Is expressed in adult head; adult heart; and organism. Orthologous to human EIF3L (eukaryotic translation initiation factor 3 subunit L). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See eIF3l in Genome Data Viewer
Location:
68F6-68F6; 3-38 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12143446..12146097, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12136546..12139197, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) SGDH subunit Neighboring gene Autophagy-related 12 Neighboring gene Rho GTPase activating protein at 68F Neighboring gene Neurexin IV Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila. Yi P, et al. Dev Cell, 2008 Nov. PMID 19000835, Free PMC Article
  2. RACK1 controls IRES-mediated translation of viruses. Majzoub K, et al. Cell, 2014 Nov 20. PMID 25416947, Free PMC Article
  3. Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing. Foley LE, et al. Elife, 2019 Nov 8. PMID 31702555, Free PMC Article
  4. TRIBE editing reveals specific mRNA targets of eIF4E-BP in Drosophila and in mammals. Jin H, et al. Sci Adv, 2020 Aug. PMID 32851185, Free PMC Article
  5. The translation factors of Drosophila melanogaster. Marygold SJ, et al. Fly (Austin), 2017 Jan 2. PMID 27494710, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit l
Names
CG5642-PA
eIF3l-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12143446..12146097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140296.3 → NP_648553.1  eukaryotic translation initiation factor 3 subunit l [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648553.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTU4
    Related
    FBpp0075754
    Conserved Domains (1) summary
    pfam10255
    Location:122 → 527
    Paf67; RNA polymerase I-associated factor PAF67
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTU4.1 Q9VTU4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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