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CAH2 Carbonic anhydrase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39390, updated on 9-Dec-2024

Summary

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Official Symbol
CAH2provided by FlyBase
Official Full Name
Carbonic anhydrase 2provided by FlyBase
Primary source
FLYBASE:FBgn0027843
Locus tag
Dmel_CG6906
See related
AllianceGenome:FB:FBgn0027843
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6906; CT21171; Dmel\CG6906
Summary
Enables carbonate dehydratase activity. Involved in one-carbon metabolic process. Predicted to be located in external side of plasma membrane. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic/larval midgut; and gastric caecum. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human CA14 (carbonic anhydrase 14) and CA4 (carbonic anhydrase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CAH2 in Genome Data Viewer
Location:
69A1-69A1; 3-38 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12177601..12183347)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12170701..12176447)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rhodopsin 7 Neighboring gene Myo-inositol oxygenase Neighboring gene Esterase 6 Neighboring gene thoc6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stable Host Gene Expression in the Gut of Adult Drosophila melanogaster with Different Bacterial Mono-Associations. Elya C, et al. PLoS One, 2016. PMID 27898741, Free PMC Article
  2. Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster. Syrjänen L, et al. Bioorg Med Chem, 2013 Mar 15. PMID 22989910
  3. Drosophila immune cells transport oxygen through PPO2 protein phase transition. Shin M, et al. Nature, 2024 Jul. PMID 38926577, Free PMC Article
  4. Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen. Helenius IT, et al. J Immunol, 2016 Jan 15. PMID 26643480, Free PMC Article
  5. Sex-specific effects of cis-regulatory variants in Drosophila melanogaster. Coolon JD, et al. Genetics, 2013 Dec. PMID 24097411, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in one-carbon metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
carbonic anhydrase 2
Names
CAH2-PA
CAH2-PB
CG6906-PA
CG6906-PB
NP_001261747.1
NP_648555.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12177601..12183347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274818.1 → NP_001261747.1  carbonic anhydrase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261747.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF87
    Conserved Domains (1) summary
    cd00326
    Location:1 → 201
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  2. NM_140298.3 → NP_648555.1  carbonic anhydrase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648555.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTU8
    Related
    FBpp0075733
    Conserved Domains (1) summary
    smart01057
    Location:28 → 281
    Carb_anhydrase; Eukaryotic-type carbonic anhydrase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PF87 M9PF87
Q9VTU8 Q9VTU8

Gene LinkOut

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