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Miox Myo-inositol oxygenase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39391, updated on 9-Dec-2024

Summary

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Official Symbol
Mioxprovided by FlyBase
Official Full Name
Myo-inositol oxygenaseprovided by FlyBase
Primary source
FLYBASE:FBgn0036262
Locus tag
Dmel_CG6910
See related
AllianceGenome:FB:FBgn0036262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6910; Dmel\CG6910; MIOX
Summary
Enables inositol oxygenase activity. Predicted to be involved in inositol catabolic process. Predicted to be located in cytoplasm. Is expressed in cardiogenic mesoderm; embryonic/larval fat body; fat body/gonad primordium; and trunk mesoderm. Orthologous to human MIOX (myo-inositol oxygenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Miox in Genome Data Viewer
Location:
69A1-69A1; 3-38 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12184984..12187860)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12178084..12180960)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Rhodopsin 7 Neighboring gene Carbonic anhydrase 2 Neighboring gene Esterase 6 Neighboring gene thoc6 Neighboring gene Esterase P

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inositol in Disease and Development: Roles of Catabolism via myo-Inositol Oxygenase in Drosophila melanogaster. Contreras A, et al. Int J Mol Sci, 2023 Feb 20. PMID 36835596, Free PMC Article
  2. Advances in Novel Animal Vitamin C Biosynthesis Pathways and the Role of Prokaryote-Based Inferences to Understand Their Origin. Duque P, et al. Genes (Basel), 2022 Oct 21. PMID 36292802, Free PMC Article
  3. Genes associated with honey bee behavioral maturation affect clock-dependent and -independent aspects of daily rhythmic activity in fruit flies. Fu C, et al. PLoS One, 2012. PMID 22606218, Free PMC Article
  4. Birth and death of genes and functions in the beta-esterase cluster of Drosophila. Robin C, et al. J Mol Evol, 2009 Jul. PMID 19536450, Free PMC Article
  5. The microbiome stabilizes circadian rhythms in the gut. Zhang Y, et al. Proc Natl Acad Sci U S A, 2023 Jan 31. PMID 36689661, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 12187580-12187654 mobile_element_type = transposon:Rt1a{}5155

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables inositol oxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol oxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol oxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inositol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in inositol catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Myo-inositol oxygenase
Names
CG6910-PB
CG6910-PC
Miox-PB
Miox-PC
myo-inositol oxygenase
NP_001261748.1
NP_648556.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12184984..12187860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274819.1 → NP_001261748.1  Myo-inositol oxygenase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261748.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PI33
    Conserved Domains (1) summary
    pfam05153
    Location:27 → 275
    MIOX; Myo-inositol oxygenase

  2. NM_140299.3 → NP_648556.3  Myo-inositol oxygenase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648556.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NMY0, Q9VTU9
    Conserved Domains (1) summary
    pfam05153
    Location:44 → 292
    MIOX; Myo-inositol oxygenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PI33 M9PI33
Q9VTU9 Q9VTU9

Gene LinkOut

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