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prkg1a protein kinase cGMP-dependent 1a [ Danio rerio (zebrafish) ]

Gene ID: 394005, updated on 27-Dec-2024

Summary

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Official Symbol
prkg1aprovided by ZNC
Official Full Name
protein kinase cGMP-dependent 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1308
See related
Ensembl:ENSDARG00000020656 AllianceGenome:ZFIN:ZDB-GENE-040426-1308
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
prkg1; zgc:63955
Summary
Predicted to enable ATP binding activity; cGMP binding activity; and cGMP-dependent protein kinase activity. Predicted to act upstream of or within protein phosphorylation. Is expressed in several structures, including female organism; nervous system; neural tube; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See prkg1a in Genome Data Viewer
Location:
chromosome: 13
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (40815015..40955718)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (40689125..40829830)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene NK1 transcription factor related 2-like,a Neighboring gene MORN repeat containing 4 Neighboring gene dickkopf WNT signaling pathway inhibitor 1a Neighboring gene protocadherin-related 15a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The role of PKG in oocyte maturation of zebrafish. Li J, et al. Biochem Biophys Res Commun, 2018 Oct 28. PMID 30269816
  2. Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses. Petit D, et al. Mol Biol Evol, 2015 Apr. PMID 25534026, Free PMC Article
  3. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article
  4. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC63955

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cGMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cGMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cGMP-dependent protein kinase 1a
Names
protein kinase, cGMP-dependent, type I
protein kinase, cGMP-dependent, type Ia
NP_957324.1
XP_005157115.1
XP_068068919.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201030.1 → NP_957324.1  cGMP-dependent protein kinase 1a

    See identical proteins and their annotated locations for NP_957324.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054581
    UniProtKB/TrEMBL
    A0A8M1PID9, Q7T2E5
    Related
    ENSDARP00000024589.7, ENSDART00000016960.9
    Conserved Domains (6) summary
    PTZ00263
    Location:338 → 657
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd12085
    Location:2 → 48
    DD_cGKI-alpha; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha
    smart00133
    Location:617 → 660
    S_TK_X; Extension to Ser/Thr-type protein kinases
    COG0664
    Location:211 → 315
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:99 → 208
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:362 → 622
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    40815015..40955718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068212818.1 → XP_068068919.1  cGMP-dependent protein kinase 1a isoform X1

  2. XM_005157058.5 → XP_005157115.1  cGMP-dependent protein kinase 1a isoform X2

    UniProtKB/TrEMBL
    A0A2R8Q8R8, A0A8M2B3F1, A0A8M3AY19
    Conserved Domains (6) summary
    PTZ00263
    Location:355 → 674
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd12086
    Location:6 → 57
    DD_cGKI-beta; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I beta
    smart00133
    Location:634 → 677
    S_TK_X; Extension to Ser/Thr-type protein kinases
    COG0664
    Location:228 → 332
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:116 → 225
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:379 → 639
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
Nucleotide Protein Strain
Heading Accession and Version

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