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cbll1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

Gene ID: 394041, updated on 4-Jan-2025

Summary

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Official Symbol
cbll1provided by ZNC
Official Full Name
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-691
See related
Ensembl:ENSDARG00000015222 AllianceGenome:ZFIN:ZDB-GENE-040426-691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55308
Summary
Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleus. Is expressed in telencephalon. Orthologous to human CBLL1 (Cbl proto-oncogene like 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See cbll1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (18836791..18841071, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (18847815..18852095, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137491543 Neighboring gene solute carrier family 26 member 3, tandem duplicate 2 Neighboring gene uncharacterized LOC110439362 Neighboring gene solute carrier family 26 member 3 Neighboring gene BCL2 interacting killer Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC55308

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Hakai
Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
NP_001296297.1
NP_001296298.1
NP_957360.2
XP_017210471.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309368.1 → NP_001296297.1  E3 ubiquitin-protein ligase Hakai isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BX649534, EH556329, EH577429
    UniProtKB/TrEMBL
    A0A8M1P6L1
    Conserved Domains (1) summary
    pfam13923
    Location:107 → 144
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

  2. NM_001309369.1 → NP_001296298.1  E3 ubiquitin-protein ligase Hakai isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    BX649534, EH556329, EH577429
    UniProtKB/TrEMBL
    A0A8M1P220, F1QLJ4
    Related
    ENSDARP00000021149.7, ENSDART00000015834.8
    Conserved Domains (1) summary
    pfam13923
    Location:1 → 25
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

  3. NM_201066.2 → NP_957360.2  E3 ubiquitin-protein ligase Hakai isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    BX649534, EH556329, EH577429
    UniProtKB/TrEMBL
    A0A8M1PDZ7, Q5RGV4
    Related
    ENSDARP00000066977.4, ENSDART00000066978.6
    Conserved Domains (1) summary
    pfam13923
    Location:100 → 137
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    18836791..18841071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017354982.3 → XP_017210471.1  E3 ubiquitin-protein ligase Hakai isoform X1

    UniProtKB/TrEMBL
    A0A8M1PDZ7, Q5RGV4
    Conserved Domains (1) summary
    pfam13923
    Location:100 → 137
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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