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CG4328 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39405, updated on 4-Jan-2025

Summary

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Official Symbol
CG4328provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036274
Locus tag
Dmel_CG4328
See related
AllianceGenome:FB:FBgn0036274
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4328
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; ganglia; midline primordium; ventral midline of embryo; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in nail-patella syndrome. Orthologous to human LMX1B (LIM homeobox transcription factor 1 beta). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG4328 in Genome Data Viewer
Location:
69A5-69B1; 3-38 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12290956..12296123, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12284056..12289223, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46241 Neighboring gene long non-coding RNA:CR45658 Neighboring gene long non-coding RNA:CR44550 Neighboring gene long non-coding RNA:CR44551

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell type-specific genomics of Drosophila neurons. Henry GL, et al. Nucleic Acids Res, 2012 Oct. PMID 22855560, Free PMC Article
  2. Micro RNAs and the biological clock: a target for diseases associated with a loss of circadian regulation. Ma Q, et al. Afr Health Sci, 2020 Dec. PMID 34394254, Free PMC Article
  3. An in vivo screen for neuronal genes involved in obesity identifies Diacylglycerol kinase as a regulator of insulin secretion. Trinh I, et al. Mol Metab, 2019 Jan. PMID 30389349, Free PMC Article
  4. The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila. Roignant JY, et al. Development, 2010 Jan. PMID 20040493, Free PMC Article
  5. Phenotypic Convergence: Distinct Transcription Factors Regulate Common Terminal Features. Konstantinides N, et al. Cell, 2018 Jul 26. PMID 29909983, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4328-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12290956..12296123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140310.3 → NP_648567.2  uncharacterized protein Dmel_CG4328 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648567.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4VCK2, B6IDR1, Q9VTW3
    Conserved Domains (4) summary
    cd09371
    Location:199 → 251
    LIM1_Lmx1b; The first LIM domain of Lmx1b
    smart00389
    Location:341 → 393
    HOX; Homeodomain
    COG5576
    Location:332 → 439
    COG5576; Homeodomain-containing transcription factor [Transcription]
    cl02475
    Location:259 → 313
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTW3 Q9VTW3

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