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arrb2b arrestin, beta 2b [ Danio rerio (zebrafish) ]

Gene ID: 394099, updated on 4-Jan-2025

Summary

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Official Symbol
arrb2bprovided by ZNC
Official Full Name
arrestin, beta 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1332
See related
Ensembl:ENSDARG00000011545 AllianceGenome:ZFIN:ZDB-GENE-040426-1332
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
arrb2; zgc:64007
Summary
Acts upstream of or within muscle organ development; regulation of receptor recycling; and regulation of signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including alar plate midbrain region; axis; brain; vasculature; and ventral mesoderm. Human ortholog(s) of this gene implicated in glioblastoma; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human ARRB2 (arrestin beta 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See arrb2b in Genome Data Viewer
Location:
chromosome: 7
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (25920805..26005199)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (25649571..25732568)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene CD99 molecule-like 2 Neighboring gene uncharacterized LOC108190781 Neighboring gene high mobility group box 3a Neighboring gene uncharacterized LOC137496167 Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene arachidonate 12-lipoxygenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Wilbanks AM, et al. Science, 2004 Dec 24. PMID 15618520
  2. β-arrestin control of late endosomal sorting facilitates decoy receptor function and chemokine gradient formation. Mahabaleshwar H, et al. Development, 2012 Aug. PMID 22791893
  3. Cone arrestin confers cone vision of high temporal resolution in zebrafish larvae. Renninger SL, et al. Eur J Neurosci, 2011 Feb. PMID 21299656
  4. Exposure of low-dose fipronil enantioselectively induced anxiety-like behavior associated with DNA methylation changes in embryonic and larval zebrafish. Qian Y, et al. Environ Pollut, 2019 Jun. PMID 30909129
  5. Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2. Burczyk M, et al. Biochemistry, 2015 Jan 27. PMID 25555130, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC64007

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of chemokine activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of receptor recycling IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
arrestin, beta 2b
Names
ARRB2b2
arrestin, beta 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201124.1 → NP_957418.1  arrestin, beta 2b

    See identical proteins and their annotated locations for NP_957418.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054595
    UniProtKB/TrEMBL
    A0A8M3B3X5, B2GPW5, Q7T2D2
    Related
    ENSDARP00000024694.6, ENSDART00000026295.9
    Conserved Domains (2) summary
    smart01017
    Location:194 → 349
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:19 → 175
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    25920805..26005199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222202.1 → XP_068078303.1  arrestin, beta 2b isoform X1

    UniProtKB/TrEMBL
    A0A8M3B109

  2. XM_009303041.4 → XP_009301316.1  arrestin, beta 2b isoform X2

    UniProtKB/TrEMBL
    A0A8M3AU12
    Conserved Domains (2) summary
    smart01017
    Location:194 → 334
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:19 → 175
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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