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Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C [ Mus musculus (house mouse) ]

Gene ID: 394432, updated on 27-Nov-2024

Summary

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Official Symbol
Ugt1a7cprovided by MGI
Official Full Name
UDP glucuronosyltransferase 1 family, polypeptide A7Cprovided by MGI
Primary source
MGI:MGI:3032636
See related
Ensembl:ENSMUSG00000090124 AllianceGenome:MGI:3032636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A13; A10'; UGT1A7; Ugt1a10
Summary
Predicted to enable several functions, including monocarboxylic acid binding activity; protein dimerization activity; and protein kinase C binding activity. Predicted to be involved in several processes, including cellular glucuronidation; coumarin catabolic process; and estrogen catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in nervous system; stomach; and urinary system. Human ortholog(s) of this gene implicated in alcoholic pancreatitis and pancreatic cancer. Orthologous to several human genes including UGT1A10 (UDP glucuronosyltransferase family 1 member A10); UGT1A7 (UDP glucuronosyltransferase family 1 member A7); and UGT1A8 (UDP glucuronosyltransferase family 1 member A8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 238.8), liver adult (RPKM 142.7) and 10 other tissues See more
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Genomic context

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See Ugt1a7c in Genome Data Viewer
Location:
1 D; 1 44.5 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88022723..88147724)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (88095001..88220002)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 pseudogene Neighboring gene predicted gene, 38421 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A9 Neighboring gene STARR-seq mESC enhancer starr_01626 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6B Neighboring gene STARR-seq mESC enhancer starr_01627 Neighboring gene STARR-seq mESC enhancer starr_01628 Neighboring gene predicted gene 15372 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6A Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 pseudogene Neighboring gene predicted gene 15371 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene predicted gene 15368 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90112870-90113171 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90113610-90113910 Neighboring gene predicted gene 15376 Neighboring gene STARR-seq mESC enhancer starr_01629 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90118277-90118578 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene STARR-positive B cell enhancer mm9_chr1:90185502-90185802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90186563-90186863 Neighboring gene Holliday junction recognition protein Neighboring gene STARR-positive B cell enhancer mm9_chr1:90195708-90196009 Neighboring gene transient receptor potential cation channel, subfamily M, member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, et al. Genome Res, 2004 Jan. PMID 14672974, Free PMC Article
  2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
  
enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
enables retinoic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables steroid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular glucuronidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular glucuronidation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in coumarin catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in estrogen catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in estrogen metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in liver development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-glucuronosyltransferase 1A7
Names
UDP glucuronosyltransferase 1 family, polypeptide A10
UDP glycosyltransferase 1 family, polypeptide A10
UDP-glucuronosyltransferase 1-7C
UDP-glucuronosyltransferase 1A7C
UDPGT 1-7C
UGT1*7C
UGT1-07C
UGT1.7C
NP_964004.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201642.4 → NP_964004.1  UDP-glucuronosyltransferase 1A7 precursor

    See identical proteins and their annotated locations for NP_964004.1

    Status: VALIDATED

    Source sequence(s)
    AC087801, AK159496, AK165465
    Consensus CDS
    CCDS15139.1
    UniProtKB/Swiss-Prot
    B2RUL6, Q6XL45, Q6ZQM8
    Related
    ENSMUSP00000058683.8, ENSMUST00000058237.14
    Conserved Domains (2) summary
    PHA03392
    Location:225 → 503
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:26 → 522
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    88022723..88147724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQM8.1 GenPept UniProtKB/Swiss-Prot:Q6ZQM8

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