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Klc Kinesin light chain [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39445, updated on 9-Dec-2024

Summary

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Official Symbol
Klcprovided by FlyBase
Official Full Name
Kinesin light chainprovided by FlyBase
Primary source
FLYBASE:FBgn0010235
Locus tag
Dmel_CG5433
See related
AllianceGenome:FB:FBgn0010235
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5433; DKLC; Dmel\CG5433; kinesin; Kinesin; klc; KLC
Summary
Predicted to enable kinesin binding activity. Involved in dorsal appendage formation and microtubule-based movement. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; ganglia; gut section; and larval muscle cell. Used to study Alzheimer's disease 1. Human ortholog(s) of this gene implicated in Alzheimer's disease; SPOAN syndrome; and relapsing-remitting multiple sclerosis. Orthologous to several human genes including KLC1 (kinesin light chain 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Klc in Genome Data Viewer
Location:
69E1-69E1; 3-39 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12746616..12750056, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12739716..12743156, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase 69D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 13D Neighboring gene Huntingtin interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tetratrico peptide repeats are present in the kinesin light chain. Gindhart JG Jr, et al. Trends Biochem Sci, 1996 Feb. PMID 8851660
  2. Kinesin-1 heavy chain mediates microtubule sliding to drive changes in cell shape. Jolly AL, et al. Proc Natl Acad Sci U S A, 2010 Jul 6. PMID 20566873, Free PMC Article
  3. Heterogeneity in kinesin function. Reddy BJN, et al. Traffic, 2017 Oct. PMID 28731566, Free PMC Article
  4. Kinesin's tail domain is an inhibitory regulator of the motor domain. Coy DL, et al. Nat Cell Biol, 1999 Sep. PMID 10559941
  5. Kinesin: the tail unfolds. Cross R, et al. Nat Cell Biol, 1999 Sep. PMID 10559950

See all (142) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinesin-1 patterns Par-1 and Rho signaling at the cortex of syncytial embryos of Drosophila.
    Title: Kinesin-1 patterns Par-1 and Rho signaling at the cortex of syncytial embryos of Drosophila.
  2. Data show that kinesin-1 spends half of each stepping cycle with one head bound, specifying a structural state for each of two rate-limiting transitions.
    Title: Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle.
  3. ensconsin promotes productive recruitment of Kinesin-1 to microtubules
    Title: Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubules.
  4. A functional consequence of myosin V's diffusion on microtubules is a significant enhancement of the processive run length of kinesin when both motors are present on the same cargo.
    Title: Myosin V and Kinesin act as tethers to enhance each others' processivity.
  5. Data show that kinesin heavy chain can function independently of the light chain in the oocyte, indicating that it associates with its cargoes by a novel mechanism.
    Title: Kinesin light chain-independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in the Drosophila oocyte.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of kinesin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinesin light chain
Names
CG5433-PA
CG5433-PB
CG5433-PC
Klc-PA
Klc-PB
Klc-PC
kinesin
kinesin 1 light chain
kinesin I
kinesin light chain subunit of kinesin-1
kinesin-1
kinesin-1 light chain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12746616..12750056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079325.3 → NP_524049.1  kinesin light chain, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524049.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P46824, Q9VU05
    UniProtKB/TrEMBL
    M9PF24
    Related
    FBpp0075683
    Conserved Domains (2) summary
    sd00006
    Location:270 → 298
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:269 → 344
    TPR_12; Tetratricopeptide repeat

  2. NM_001274852.1 → NP_001261781.1  kinesin light chain, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261781.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFG7
    Conserved Domains (2) summary
    sd00006
    Location:270 → 298
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:269 → 344
    TPR_12; Tetratricopeptide repeat

  3. NM_001274851.1 → NP_001261780.1  kinesin light chain, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261780.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P46824, Q9VU05
    UniProtKB/TrEMBL
    M9PF24
    Conserved Domains (2) summary
    sd00006
    Location:270 → 298
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:269 → 344
    TPR_12; Tetratricopeptide repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PF24 M9PF24
M9PFG7 M9PFG7
P46824.1 P46824

Gene LinkOut

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