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Ent3 Equilibrative nucleoside transporter 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39461, updated on 4-Jan-2025

Summary

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Official Symbol
Ent3provided by FlyBase
Official Full Name
Equilibrative nucleoside transporter 3provided by FlyBase
Primary source
FLYBASE:FBgn0036319
Locus tag
Dmel_CG11010
See related
AllianceGenome:FB:FBgn0036319
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11010; Dmel\CG11010; DmEnt3; DmENT3; ent3; ENT3
Summary
Predicted to enable monoamine transmembrane transporter activity and nucleoside transmembrane transporter activity. Predicted to be involved in nucleoside transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to human SLC29A4 (solute carrier family 29 member 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Ent3 in Genome Data Viewer
Location:
69E6-69E6; 3-39 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12853646..12857428)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12846746..12850528)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene WW domain binding protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity. Sankar N, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384580, Free PMC Article
  2. Genomic analysis of nucleoside transporters in Diptera and functional characterization of DmENT2, a Drosophila equilibrative nucleoside transporter. Machado J, et al. Physiol Genomics, 2007 Feb 12. PMID 17090699
  3. Equilibrative nucleoside transporter 2 regulates associative learning and synaptic function in Drosophila. Knight D, et al. J Neurosci, 2010 Apr 7. PMID 20371825, Free PMC Article
  4. Adenosine Receptor and Its Downstream Targets, Mod(mdg4) and Hsp70, Work as a Signaling Pathway Modulating Cytotoxic Damage in Drosophila. Lin YH, et al. Front Cell Dev Biol, 2021. PMID 33777958, Free PMC Article
  5. Delineating Purinergic Signaling in Drosophila. Volonté C, et al. Int J Mol Sci, 2022 Dec 2. PMID 36499534, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables monoamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleoside transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleoside transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
equilibrative nucleoside transporter 3
Names
CG11010-PA
CG11010-PB
CG11010-PC
Ent3-PA
Ent3-PB
Ent3-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12853646..12857428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300123.1 → NP_001287052.1  equilibrative nucleoside transporter 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287052.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961M5, Q9VU20
    Conserved Domains (1) summary
    cl15430
    Location:60 → 529
    Nucleoside_tran; Nucleoside transporter

  2. NM_001274859.2 → NP_001261788.1  equilibrative nucleoside transporter 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261788.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PI48, Q961M5
    Conserved Domains (1) summary
    cl15430
    Location:60 → 528
    Nucleoside_tran; Nucleoside transporter

  3. NM_140351.3 → NP_648608.2  equilibrative nucleoside transporter 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648608.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961M5, Q9VU20
    Related
    FBpp0075667
    Conserved Domains (1) summary
    cl15430
    Location:60 → 529
    Nucleoside_tran; Nucleoside transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PI48 M9PI48
Q961M5 Q961M5
Q9VU20 Q9VU20

Gene LinkOut

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