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PROC protein C, inactivator of coagulation factors Va and VIIIa [ Gallus gallus (chicken) ]

Gene ID: 395085, updated on 3-Dec-2024

Summary

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Official Symbol
PROCprovided by CGNC
Official Full Name
protein C, inactivator of coagulation factors Va and VIIIaprovided by CGNC
Primary source
CGNC:1251
See related
Ensembl:ENSGALG00010023116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See PROC in Genome Data Viewer
Location:
chromosome: 9
Exon count:
9
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (903313..912582)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (771756..781025)

Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112533001 Neighboring gene S-antigen visual arrestin Neighboring gene diacylglycerol kinase delta Neighboring gene coagulation factor IX-like Neighboring gene IWS1, SUPT6H interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
vitamin K-dependent protein C
Names
anticoagulant protein C
NP_001384817.1
NP_001384818.1
NP_989772.2
XP_015132295.2
XP_025009072.2
XP_046754259.1
XP_046779496.1
XP_046779497.1
XP_046779498.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397888.1 → NP_001384817.1  vitamin K-dependent protein C isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240
    UniProtKB/TrEMBL
    Q804X5
    Conserved Domains (3) summary
    smart00069
    Location:21 → 84
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:85 → 119
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:192 → 423
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001397889.1 → NP_001384818.1  vitamin K-dependent protein C isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240

  3. NM_204441.2 → NP_989772.2  vitamin K-dependent protein C isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000240
    UniProtKB/TrEMBL
    Q804X5
    Conserved Domains (3) summary
    smart00069
    Location:21 → 84
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:85 → 119
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:192 → 423
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    903313..912582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015276809.4 → XP_015132295.2  vitamin K-dependent protein C isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZTG6, Q804X5
    Related
    ENSGALP00010034109.1, ENSGALT00010056341.1
    Conserved Domains (3) summary
    smart00069
    Location:44 → 107
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:108 → 142
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:215 → 446
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_046898303.1 → XP_046754259.1  vitamin K-dependent protein C isoform X3

  3. XM_025153304.3 → XP_025009072.2  vitamin K-dependent protein C isoform X2

    UniProtKB/TrEMBL
    Q804X5
    Conserved Domains (2) summary
    smart00069
    Location:44 → 107
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00190
    Location:178 → 409
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    771756..781025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046923540.1 → XP_046779496.1  vitamin K-dependent protein C isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZTG6, Q804X5

  2. XM_046923542.1 → XP_046779498.1  vitamin K-dependent protein C isoform X3

  3. XM_046923541.1 → XP_046779497.1  vitamin K-dependent protein C isoform X2

    UniProtKB/TrEMBL
    Q804X5
Nucleotide Protein
Heading Accession and Version

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