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cmb combover [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39513, updated on 4-Jan-2025

Summary

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Official Symbol
cmbprovided by FlyBase
Official Full Name
comboverprovided by FlyBase
Primary source
FLYBASE:FBgn0036365
Locus tag
Dmel_CG10732
See related
AllianceGenome:FB:FBgn0036365
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10732; Cmb; Dmel\CG10732; NEST:bs28e06
Summary
Involved in imaginal disc-derived wing hair organization and sperm individualization. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; ganglia; and larval somatic muscle cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See cmb in Genome Data Viewer
Location:
70B1-70B1; 3-40 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13442594..13449245)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13435694..13442345)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Jumonji domain containing 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Detecting New Allies: Modifier Screen Identifies a Genetic Interaction Between Imaginal disc growth factor 3 and combover, a Rho-kinase Substrate, During Dorsal Appendage Tube Formation in Drosophila. Espinoza CY, et al. G3 (Bethesda), 2020 Oct 5. PMID 32855169, Free PMC Article
  2. Combover/CG10732, a novel PCP effector for Drosophila wing hair formation. Fagan JK, et al. PLoS One, 2014. PMID 25207969, Free PMC Article
  3. Combover interacts with the axonemal component Rsp3 and is required for Drosophila sperm individualization. Steinhauer J, et al. Development, 2019 Sep 2. PMID 31391193, Free PMC Article
  4. Expression profiling of a hypercontraction-induced myopathy in Drosophila suggests a compensatory cytoskeletal remodeling response. Montana ES, et al. J Biol Chem, 2006 Mar 24. PMID 16415344
  5. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Lowe N, et al. Development, 2014 Oct. PMID 25294943, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in imaginal disc-derived wing hair organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
combover
Names
CG10732-PA
CG10732-PB
CG10732-PC
CG10732-PD
cmb-PA
cmb-PB
cmb-PC
cmb-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13442594..13449245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168546.3 → NP_729901.1  combover, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729901.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VU76
    Related
    FBpp0075586
    Conserved Domains (1) summary
    COG1196
    Location:339 → 720
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_001274872.1 → NP_001261801.1  combover, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261801.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFI2
    Conserved Domains (1) summary
    COG1196
    Location:339 → 720
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. NM_001274873.1 → NP_001261802.1  combover, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261802.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFE5
    Conserved Domains (1) summary
    COG1196
    Location:339 → 720
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. NM_140393.4 → NP_648650.1  combover, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648650.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961X4
    Related
    FBpp0075587
    Conserved Domains (1) summary
    COG1196
    Location:61 → 442
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFE5 M9PFE5
M9PFI2 M9PFI2
Q961X4 Q961X4
Q9VU76 Q9VU76

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