OTX2 orthodenticle homeobox 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: OTX2provided by CGNC
Full Name: orthodenticle homeobox 2provided by CGNC
Primary source: CGNC:66196
See related: Ensembl:ENSGALG00010019688
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (55389736..55396825)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (55429563..55436665)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification.
Title: OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification.
Otx2 and Onecut1 are coexpressed in retinal progenitors and coregulate cis-regulatory module for the thyroid hormone receptor beta gene.
Title: Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors.
Otx2 prevents the presumptive retinal pigment epithelium region from forming the neural retina (NR) by repressing the expression of both Fgf8 and Sox2 which induce the NR cell fate.
Title: Otx2 is involved in the regional specification of the developing retinal pigment epithelium by preventing the expression of sox2 and fgf8, factors that induce neural retina differentiation.
OTX2 is down-regulated in chick embryos in sodium arsenite-induced neural tube defects.
Title: MiR-206 regulates neural cells proliferation and apoptosis via Otx2.
Otx2 and Gbx2 provide a global mechanism for patterning of the embryonic ectoderm and ensure the coordinated development of the central and peripheral nervous system in the head.
Title: Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning.
Results suggest that the interaction between Otx2 and Gbx2 in developing inner ear defines Fgf10 expression domain to induce the cochlear ganglion.
Title: Role of Gbx2 and Otx2 in the formation of cochlear ganglion and endolymphatic duct.
Otx2, Gbx2, and Fgf8 are expressed in the chick developing inner ear
Title: Otx2, Gbx2, and Fgf8 expression patterns in the chick developing inner ear and their possible roles in otic specification and early innervation.
Chick embryo torus semicircularis (the inferior colliculus homolog) expressed Otx2 in its ventricular lining exclusively. The parvicellular isthmic nucleus never expressed Otx2.
Title: A distinct preisthmic histogenetic domain is defined by overlap of Otx2 and Pax2 gene expression in the avian caudal midbrain.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: homeobox protein OTX2

Names: orthodenticle homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204520.2 → NP_989851.2 homeobox protein OTX2

See identical proteins and their annotated locations for NP_989851.2

Status: PROVISIONAL

Source sequence(s)

AY600957

UniProtKB/TrEMBL

Q6E236, Q8JG31

Conserved Domains (3) summary

COG5576
Location:36 → 159

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:42 → 94

Homeobox; Homeobox domain

pfam03529
Location:155 → 234

TF_Otx; Otx1 transcription factor

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

55389736..55396825

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015287272.4 → XP_015142758.1 homeobox protein OTX2 isoform X1

UniProtKB/TrEMBL

Q6E236, Q8JG31

Related

ENSGALP00010028140.1, ENSGALT00010047527.1

Conserved Domains (3) summary

COG5576
Location:36 → 159

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:42 → 94

Homeobox; Homeobox domain

pfam03529
Location:155 → 234

TF_Otx; Otx1 transcription factor